Mechanisms underlying different responses of plasma triglyceride to high-fat diets in hamsters and mice: Roles of hepatic MTP and triglyceride secretion
Mechanisms underlying different responses of plasma triglyceride to high-fat diets in hamsters and mice: Roles of hepatic MTP and triglyceride secretion
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DOI：
10.1016/j.bbrc.2010.05.114
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发表时间：
2010-08-06
影响因子：
3.1
通讯作者：
Liu, George
中科院分区：
文献类型：
--
作者：
Gao, Song;He, Liang;Liu, George
高脂血症与胰岛素抵抗密切相关，在人类中由高脂饮食（HFD）诱导，但在小鼠模型中不诱导。这种物种差异的机制尚不清楚。仓鼠的脂蛋白代谢与人类相似。通过比较仓鼠和小鼠对HFD的反应，我们发现，在HID喂养的仓鼠中，肝脏TG分泌、MTP表达和血浆游离脂肪酸（FFA）水平增加，而在小鼠中，肝脏TG分泌、MTP表达和FFA水平降低。虽然在这两种模型中，HFD喂养均诱导了肝脂肪变性和新生脂肪生成，但在小鼠中胆固醇生物合成受到抑制，而在仓鼠中则没有。在胰岛素缺乏状态下，高脂饮食可增加血浆TG水平和肝脏TG分泌。两种模型中MTP表达和血浆FFA水平。总之，MTP表达的明显变化，与肝脏TG分泌相关，是仓鼠和小鼠血浆TG水平对高脂饮食的相反反应的基础。此外，肝TG分泌和MTP表达似乎与血浆FFA水平和胆固醇生物合成有关，但与肝脂肪变性或新生脂肪生成无关。(c)2010年爱思唯尔公司All rights reserved.
Hypertriglyceridemia, closely associated with insulin resistance, is induced on high-fat diets (HFD) in humans but not in mouse models. Mechanisms underlying this species difference are still unclear. Hamsters resemble humans in lipoprotein metabolism. Here by comparing the responses to HFD in hamsters and mice, we found that hepatic TG secretion, MTP expression and plasma free fatty acid (FFA) level were increased in hamsters on HID feeding but decreased in mice. Although hepatic steatosis and de novo lipogenesis were induced by HFD feeding in both models, cholesterol biosynthesis was inhibited in mice but not in hamsters. Moreover, in insulin deficient state, HFD increased plasma TG level, hepatic TG secretion. MTP expression and plasma FFA level in both models. In summary, distinct changes of MTP expression, in correlation with hepatic TG secretion, underlie the opposite responses of plasma TG levels to high-fat diets in hamsters and mice. Furthermore, hepatic TG secretion and MTP expression seems to be associated with plasma FFA level and cholesterol biosynthesis but not hepatic steatosis or de novo lipogenesis. (c) 2010 Elsevier Inc. All rights reserved.