Paper-Based Blood Typing Device That Reports Patient's Blood Type "in Writing"
Paper-Based Blood Typing Device That Reports Patient's Blood Type "in Writing"
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DOI：
10.1002/anie.201201822
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发表时间：
2012-01-01
影响因子：
16.6
通讯作者：
Shen, Wei
中科院分区：
文献类型：
--
作者：
Li, Miaosi;Tian, Junfei;Shen, Wei
英国作家JK罗琳在她的小说《哈利波特与密室》中提出了一个有远见的想法，即人们可以从一张纸上询问信息，并从纸上得到明确的书面答案。在这里，我们报告了一项研究，按照她的愿景，使用低成本的生物活性纸设备进行ABO和恒河猴（RhD）血型测试，并获得书面的论文测试结果。设计和打印纸质文本图案，以允许分组抗体和红细胞之间的相互作用。由生物活性和非生物活性部分组成的复合文本模式用于形成测试报告最终显示的字母和符号。这种基于纸张的血型检测设备可以以明确的书面文本快速报告患者的血型。图案化生物活性纸作为生化分析工具已成为制造低成本和用户操作的诊断设备的平台，[1]护理点（POC），[1-6]病原体和生物标志物检测，[1，4，5]以及食品和饮用水质量检测。[7]该平台为发展中国家提供负担得起、快速和用户友好的诊断传感器，用于疾病筛查、医疗保健和饮用水质量评估的潜力越来越明显。[1，4，8-10]在过去的五年中，生物活性纸基低成本传感器制造的研究激增，[1，3，4，11-16]用于实时诊断的比色测定的电子传输，[6，17]以及使用低成本传感器的新诊断和环境应用。[6，7，18-21]比色和电化学方法是生物活性纸传感器的首选分析方法，因为这些方法被证明在定性和半定量传感中有效，并且可以很容易地适应纸。[3，6，21，22]然而，这些研究也揭示了这些新概念在实际应用中的某些局限性。虽然比色法或伏安法
The British author, JK Rowling, presented a visionary idea in her novel “Harry Potter and the Chamber of Secrets” that one can interrogate a piece of paper for information and get unambiguous answers from the paper in writing. Here we report a study, following her vision, on using a low-cost bioactive paper device to perform ABO and rhesus (RhD) blood typing tests and obtain test results from the paper in writing. Paper text patterns are designed and printed to allow interactions between grouping antibodies and red blood cells. Composite text patterns consisting of the bioactive and nonbioactive sections are used to form the letters and symbols for the final display of the testing report. This paper-based blood typing device rapidly reports patient s blood type in unambiguous written text.Patterned bioactive paper as a tool for biochemical analysis has become a platform for making low-cost and user-operated devices for diagnosis,[1] point of care (POC),[1–6] pathogen and biomarker detection,[1, 4, 5] and food and drinking water quality testing.[7] The potential of this platform to deliver affordable, rapid, and user-friendly diagnostic sensors for disease screening, healthcare and drinking water quality evaluation to the developing countries has become increasingly clear.[1, 4, 8–10] Over the last five years, there has been an explosion of research in bioactive paper-based low-cost sensor fabrication,[1, 3, 4, 11–16] electronic transmission of colorimetric assays for real-time diagnosis,[6, 17] as well as new diagnostic and environmental applications using low-cost sensors.[6, 7, 18–21] Colorimetric and electrochemical methods are the preferred analytical approaches for bioactive paper sensors, since these methods are proven to be effective in qualitative and semi-quantitative sensing and can be easily adapted onto paper.[3, 6, 21, 22] However, those studies also revealed certain limitations of those new concepts in their practical applications. Whilst a colorimetric or voltammetric