Cohort Profile: The Born in Bradford multi-ethnic family cohort study
Cohort Profile: The Born in Bradford multi-ethnic family cohort study
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DOI：
10.1093/ije/dys112
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发表时间：
2013-08-01
影响因子：
7.7
通讯作者：
West, Jane
中科院分区：
文献类型：
--
作者：
Wright, John;Small, Neil;West, Jane
“出生于布拉德福德”队列研究成立于 2007 年，旨在研究遗传、营养、环境、行为和社会因素如何影响贫困多种族人群的儿童期健康和发展以及随后的成年生活。 2007年至2011年间，从12453名怀孕13776次的妇女（以28周美元招募）及其3448名伴侣收集了有关社会经济特征、种族和家谱、生活方式因素、环境风险因素以及身心健康的详细信息。母亲在招募时进行称重和测量，婴儿在出生时和产后至 2 岁时进行详细的人体测量评估。妊娠 28 周时，获得了母亲的口服葡萄糖耐量试验和血脂谱结果，并储存了妊娠血清、血浆和尿液样本。脐带血样本已获得并储存，10000 对母子的脱氧核糖核酸 (DNA) 提取也即将完成。该研究拥有超过 250000 个母体血液、DNA 和尿液、脐带血和 DNA 以及父亲唾液样本的生物库。此队列简介中提供了科学家如何访问这些数据的详细信息。
The Born in Bradford cohort study was established in 2007 to examine how genetic, nutritional, environmental, behavioural and social factors impact on health and development during childhood, and subsequently adult life in a deprived multi-ethnic population. Between 2007 and 2011, detailed information on socio-economic characteristics, ethnicity and family trees, lifestyle factors, environmental risk factors and physical and mental health has been collected from 12453 women with 13776 pregnancies (recruited at $28 weeks) and 3448 of their partners. Mothers were weighed and measured at recruitment, and infants have had detailed anthropometric assessment at birth and post-natally up to 2 years of age. Results of an oral glucose tolerance test and lipid profiles were obtained on the mothers during pregnancy at $28 weeks gestation, and pregnancy serum, plasma and urine samples have been stored. Cord blood samples have been obtained and stored and Deoxyribonucleic acid (DNA) extraction on 10000 mother–offspring pairs is nearly completed. The study has a biobank of over 250000 samples of maternal blood, DNA and urine, cord blood and DNA and paternal saliva. Details of how scientists can access these data are provided in this cohort profile.