ON THE INTENSITY-TIME RELATIONS FOR STIMULATION BY ELECTRIC CURRENTS. I.
ON THE INTENSITY-TIME RELATIONS FOR STIMULATION BY ELECTRIC CURRENTS. I.
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DOI：
10.1085/jgp.15.6.709
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发表时间：
1932-07-20
影响因子：
3.8
通讯作者：
Blair, H A
中科院分区：
文献类型：
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作者：
Blair, H A
公式推导出的时间-强度关系的刺激由直流电使用以下假设：第一，电流产生的兴奋效应，其增长率是成比例的电压;和第二，组织反应向正常状态的速率成比例的量的激励。如果p用数值表示局部兴奋过程，则假设由微分方程表示。其中K和k是常数，V是施加的电压。为了使刺激足够，假设p必须建立到某个阈值。从数据中可以推断出，这个阈值是电压的函数，形式为h ± αV，其中h和α是常数。对于某些电极，α为零或可忽略。αV是电紧张或类似现象的量度。实验数据进行了讨论，并与导出的公式在阳极和阴极的刺激令人满意地同意。
Formulae are derived for the time-intensity relations for stimulation by direct currents using the following hypotheses: first, the current produces an excitatory effect whose rate of growth is proportional to the voltage; and second, the tissue reacts toward the normal state at a rate proportional to the amount of excitation. If p represents the local excitatory process numerically, the hypotheses are represented by the differential equation See PDF for Structure. where K and k are constants and V the applied voltage. For the stimulus to be adequate it is assumed that p must be built up to a certain liminal value. It appears as a deduction from the data that this liminal value is a function of the voltage of the form h ± αV where h and α are constants. α is zero or negligible for certain electrodes. αV is a measure of electrotonus or a similar phenomenon. Experimental data are discussed and are shown to agree satisfactorily with the derived formulae for stimulation both at the anode and cathode.