Association of pre-S deletion mutant of hepatitis B virus with risk of hepatocellular carcinoma
Association of pre-S deletion mutant of hepatitis B virus with risk of hepatocellular carcinoma
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DOI：
10.1111/j.1440-1746.2006.04515.x
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发表时间：
2007-07-01
影响因子：
4.1
通讯作者：
Kao, Jia-Horng
中科院分区：
文献类型：
--
作者：
Lin, Chih-Lin;Liu, Chen-Hua;Kao, Jia-Horng
背景：乙型肝炎病毒（HBV）的Pre-S缺失突变体影响中、小表面蛋白的表达，导致大表面蛋白在细胞内积累。乙型肝炎病毒携带者中pre-S缺失突变体与肝细胞癌(HCC)风险之间的相关性尚不清楚。方法：采用分子检测方法，在266例慢性乙型或丙型乙型肝炎病毒感染患者中测定了HBV前S缺失突变体。其中包括202名无症状携带者和64名HCC患者。结果：pre-S缺失突变体的总体患病率为16.5%。肝细胞癌（比值比 [OR]，3.23；95% 置信区间 [CI]，1.23-8.48，P = 0.02）和基因型 C（OR，3.19；95% CI，1.54-6.62，P = 0.002）与 pre-S 缺失突变体的存在独立相关。基因型 B 和 C 感染的 HCC 患者中前 S 缺失突变体的患病率相当。然而，在无症状携带者中，与 B 基因型感染患者相比，C 基因型感染患者与 pre-S 缺失突变体的存在显着相关（20.8% vs 7.2%，P = 0.007）。与年龄和基因型B匹配的无症状携带者相比，年轻HCC患者（<50岁）的pre-S缺失频率显着较高（3.4% vs 20%，P=0.04）。结论：Pre-S缺失突变体在C基因型感染的HBV携带者中更为常见，无论HBV基因型如何，pre-S缺失突变体可能与HCC的发生有关。
Background: Pre-S deletion mutant of hepatitis B virus (HBV) affects the expression of middle and small surface proteins, resulting in intracellular accumulation of large surface protein. The correlation between pre-S deletion mutant and risk of hepatocellular carcinoma (HCC) in hepatitis B virus carriers remains unclear.Methods: Using molecular assays, pre-S deletion mutant of HBV were determined in 266 patients with chronic HBV genotype B or C infection. They included 202 asymptomatic carriers and 64 HCC patients.Results: The overall prevalence of pre-S deletion mutant was 16.5%. Hepatocellular carcinoma (odds ratio [OR], 3.23; 95% confidence interval [CI], 1.23-8.48, P = 0.02) and genotype C (OR, 3.19; 95%CI, 1.54-6.62, P = 0.002) were independently associated with the presence of pre-S deletion mutant. The prevalence of pre-S deletion mutant was comparable between HCC patients with genotype B and C infection. Nevertheless, in asymptomatic carriers, patients with genotype C infection were significantly associated with the presence of pre-S deletion mutant compared to those with genotype B infection (20.8% vs 7.2%, P = 0.007). Compared with age- and genotype B-matched asymptomatic carriers, young HCC patients (< 50 years of age) had a significantly higher frequency of pre-S deletion (3.4% vs 20%, P = 0.04).Conclusions: Pre-S deletion mutant is more frequent in HBV carriers with genotype C infection, and those with pre-S deletion mutant may be associated with the development of HCC, irrespective of HBV genotype.