Middle cerebral artery blood flows by combining TCD velocities and MRA diameters: in vitro and in vivo validations.
Middle cerebral artery blood flows by combining TCD velocities and MRA diameters: in vitro and in vivo validations.
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DOI：
10.1016/j.ultrasmedbio.2014.05.022
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发表时间：
2014-11
影响因子：
2.9
通讯作者：
Roldan CA
中科院分区：
文献类型：
--
作者：
Yonan KA;Greene ER;Sharrar JM;Caprihan A;Qualls C;Roldan CA
无创经颅多普勒（TCD）被广泛用于测量人大脑中动脉（MCA）的血流速度（BV，cm/sec）。MCABV测量值与MCA血流（MCABF）呈线性关系。磁共振血管造影（MRA）提供MCA管腔直径的测量值，可与TCD MCABV结合计算MCABF（ml/min）。我们测试了该方法对流量体模和体内近端颈内动脉血流（ICABF）的精密度和准确度。体外精密度（重复测量）和准确度（相对于收集时间）的相关系数分别为0.97和0.98（均为p<0.05）。体内精密度（重复测量）和准确度（相对于ICABF）的相关系数分别为0.90（左和右）、0.94（左）和0.93（右）（均p<0.05）。35名成人的双侧MCABF相似（左侧，168±72 ml/min;右侧，180±69 ml/min; p>0.05）。结果表明，TCD血流速度和MRA管腔直径可以联合估计MCABF的绝对值。
Noninvasive transcranial Doppler (TCD) is widely used for blood velocity (BV, cm/sec) measurements in the human middle cerebral artery (MCA). MCABV measurements are accepted as linear with MCA blood flow (MCABF). Magnetic resonance angiography (MRA) provides measurements of MCA lumen diameters that can be combined with TCD MCABV to calculate MCABF (ml/min). We tested the precision and accuracy of this method against a flow phantom and in vivo proximal internal carotid artery blood flow (ICABF). In vitro precision (repeated measures) and accuracy (versus time collection) gave correlations coefficients of 0.97 and 0.98; respectfully (both p<0.05). In vivo precision (repeated measures) and accuracy (versus ICABF) gave correlation coefficients of 0.90 (left and right), and 0.94 (left) and 0.93 (right) (all p<0.05). Bilateral MCABF in 35 adults were similar (left, 168±72 ml/min; right, 180±69 ml/min; p>0.05). Results suggest that blood velocity by TCD and lumen diameter by MRA can be combined to estimate absolute values of MCABF.