Development of antibody isotype responses to Schistosoma mansoni in an immunologically naive immigrant population:: Influence of infection duration, infection intensity, and host age
Development of antibody isotype responses to Schistosoma mansoni in an immunologically naive immigrant population:: Influence of infection duration, infection intensity, and host age
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DOI：
10.1128/iai.67.7.3444-3451.1999
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发表时间：
1999-07-01
影响因子：
3.1
通讯作者：
Dunne, DW
中科院分区：
文献类型：
--
作者：
Naus, CWA;Kimani, G;Dunne, DW
我们已经确定了宿主和寄生虫因素的影响，这些因素导致了在不同血吸虫病流行地区的人群中看到的具有特征的抗体同型图谱。这在这种疾病的免疫生物学中很重要。对人类对慢性抗原刺激、疫苗、过敏原和其他病原体的反应的竞争也很感兴趣。在接触地方性血吸虫病的人群中，感染强度和持续时间等因素与年龄有关。因此，他们混淆了寄主年龄对抗寄生虫反应的影响。在这里，我们通过比较免疫幼稚的移民人口首次感染时的抗体反应与肯尼亚同一地区曼氏血吸虫流行地区的长期感染居民的抗体反应，解决了这些混杂因素。最近到达该地区的人强烈支持针对该寄生虫的免疫球蛋白G3(IgG3)反应。与人类化疗后再感染易感性相关的抗体同型反应在感染强度高的患者中升高(抗虫卵抗原的IgG4反应)，或无论感染强度或持续时间如何都是幼儿特有的反应(抗虫卵抗原的IgG2反应)。对成虫的免疫球蛋白E反应是一种与化疗后抵抗再感染有关的反应，随着感染者的年龄增加，也受到目前感染强度较高的人的青睐。
We have identified the influence of host and parasite factors that give rise to characteristic antibody isotype profiles,vith age seen in human populations living in different areas of schistosomiasis endemicity. This is important in the immunobiology of this disease. It is also of interest in the contest of human responses to chronic antigen stimulation, vaccines, allergens, and other pathogens. In populations exposed to endemic schistosomiasis, factors such as intensity and duration of infection are age dependent. They therefore confound the influence of host age on antiparasite responses. Here, we resolved these confounding factors by comparing the developing antibody responses of an immunologically naive immigrant population as they acquired the infection for the first time with those of chronically infected resident inhabitants of the same region of Schistosoma mansoni endemicity in Kenya. Recent arrival in the area strongly favored immunoglobulin G3 (IgG3) responses against the parasite. The antibody isotype responses associated with human susceptibility to reinfection after chemotherapy were elevated in those suffering high intensities of infection (IgG4 responses against worm and egg antigens) or were characteristic responses of young children irrespective of the intensity or duration of infection (IgG2 responses against egg antigen). IgE responses against the adult worm, a response associated with resistance to reinfection after chemotherapy, increased with the ages of infected individuals and were also favored in those currently suffering higher intensities of infection.