Age-Related Differences in Functional Connectivity During Cognitive Emotion Regulation
Age-Related Differences in Functional Connectivity During Cognitive Emotion Regulation
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DOI：
10.1093/geronb/gbu108
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发表时间：
2014-11-01
影响因子：
6.2
通讯作者：
Kensinger, Elizabeth A.
中科院分区：
文献类型：
--
作者：
Allard, Eric S.;Kensinger, Elizabeth A.
目标。成功的情绪调节部分取决于我们通过使用认知策略来调节情绪反应的能力。年龄可能会影响最常用的策略；因此，我们研究了年轻人和老年人在使用两种不同的策略：认知重评价和选择性注意时的神经网络连通性。由于前扣带皮层（ACC）是情绪调节网络的核心部分，随着年龄的增长，该区域呈现出相对的结构保存，因此目前的研究使用心理生理相互作用分析来检查其与该区域的功能连通性。在选择性注意和被动观看条件下，ACC和前额叶皮层（PFC）之间的功能连通性在两个年龄组中都更大。对于年轻人，在重新评估时，ACC与PFC外侧背外侧、PFC腹外侧、PFC背内侧和后扣带区联系更紧密。对于老年人，在重新评估过程中，主要在腹内侧PFC和眶额皮质观察到更强的连通性。我们的研究结果表明，尽管年轻人和老年人在调节过程中参与PFC网络，特别是在重新评估过程中，但这些网络中的区域可能不同。此外，这些结果表明，尽管先前有证据表明这些区域的结构和功能与年龄有关，但老年人能够在情绪调节过程中招募ACC和PFC区域作为连贯网络的一部分。
Objectives. Successful emotion regulation partly depends on our capacity to modulate emotional responses through the use of cognitive strategies. Age may affect the strategies employed most often; thus, we examined younger and older adults' neural network connectivity when employing two different strategies: cognitive reappraisal and selective attention.Method. The current study used psychophysiological interaction analyses to examine functional connectivity with a region of anterior cingulate cortex (ACC) because it is a core part of an emotion regulation network showing relative structural preservation with age.Results. Functional connectivity between ACC and prefrontal cortex (PFC) was greater for reappraisal relative to selective attention and passive viewing conditions for both age groups. For younger adults, ACC was more strongly connected with lateral dorsolateral PFC, ventrolateral PFC, dorsomedial PFC, and posterior cingulate regions during reappraisal. For older adults, stronger connectivity during reappraisal was observed primarily in ventromedial PFC and orbitofrontal cortex.Discussion. Our results suggest that although young and older adults engage PFC networks during regulation, and particularly during reappraisal, the regions within these networks might differ. Additionally, these results clarify that, despite prior evidence for age-related declines in the structure and function of those regions, older adults are able to recruit ACC and PFC regions as part of coherent network during emotion regulation.