Suppression of tumor growth at the site of infection with living Bacillus Calmette-Guérin.
Suppression of tumor growth at the site of infection with living Bacillus Calmette-Guérin.
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用活卡介苗抑制感染部位的肿瘤生长。
DOI：
10.1093/jnci/46.4.831
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发表时间：
1971
期刊：
影响因子：
--
通讯作者：
H. Rapp
中科院分区：
文献类型：
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作者：
B. Zbar;I. Bernstein;H. Rapp
评价了活卡介苗（BCG）感染对肿瘤生长的影响。当在肿瘤接种部位发生活BCG感染时，观察到完全的肿瘤抑制。这种对肿瘤生长的抑制并不归因于活BCG对肿瘤细胞的直接细胞毒性作用。肿瘤生长的抑制是由宿主在对感染生物体的迟发型超敏反应期间介导的。在BCG感染部位排斥肿瘤细胞的动物表现出抑制肿瘤生长和对随后的肿瘤细胞攻击的迟发型超敏反应。在免疫动物和未免疫动物中，能够引起宿主应答并完全杀死肿瘤细胞的活BCG的最小数量分别为6 × 106个和6 × 105个。肿瘤的最佳抑制需要活的BCG，肿瘤和BCG之间的密切接触，以及宿主的细胞介导的免疫应答。
The effect of infection with living Bacillus Calmette-Guérin (BCG) on tumor growth was evaluated. Complete tumor inhibition was observed when infection with living BCG occurred at the site of tumor inoculation. This inhibition of tumor growth was not attributable to a direct cytotoxic effect of living BCG on tumor cells. Inhibition of tumor growth was mediated by the host during a delayed hypersensitivity-type immunologic response to the infecting organisms. Animals that rejected tumor cells at the site of an infection with BCG showed suppressed tumor growth and delayed hypersensitivity reactions to a subsequent challenge of tumor cells. The minimum number of living BCG capable of eliciting a host response that would completely kill tumor cells was 6 × 106organisms in immunized and 6 × 105organisms in unimmunized animals. Optimal suppression of tumor required living BCG, close contact between tumor and BCG, and a cell-mediated immune response by the host.