Metastatic prostate cancer: Initial findings of PET with 2-deoxy-2-[F-18]fluoro-D-glucose
Metastatic prostate cancer: Initial findings of PET with 2-deoxy-2-[F-18]fluoro-D-glucose
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DOI：
10.1148/radiology.199.3.8638000
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发表时间：
1996-06-01
期刊：
影响因子：
19.7
通讯作者：
Wahl, RL
中科院分区：
文献类型：
--
作者：
Shreve, PD;Grossman, HB;Wahl, RL
目得：为了评估的准确性，正电子发射断层扫描（PET）与2-脱氧-2 [氟-18]氟-D-葡萄糖（FDG）在检测骨和软组织转移的前列腺癌。材料和方法：34例（平均年龄，71岁）活检证实的前列腺癌和已知或怀疑转移性疾病进行了检查。PET图像的盲法解释进行了比较，骨扫描，CT和临床随访findings.Results：在202未经治疗的骨转移瘤22例，FDG PET的敏感性为65%（131 202转移），阳性预测值为98%（131 133阳性结果）。转移瘤的估计标准化摄取值为2.1-5.7。软组织转移到淋巴结或肝脏被确定，但盆腔淋巴结转移的评估是严重限制，因为膀胱示踪剂activity.CONCLUSION：FDG PET可以帮助确定前列腺癌的骨和软组织转移具有较高的阳性预测值，但在骨转移的识别比骨显像敏感性低。
PURPOSE: To evaluate the accuracy of positron emission tomography (PET) with 2-deoxy-2[fluorine-18]fluoro-D-glucose (FDG) in the detection of osseous and soft-tissue metastases of prostate cancer.MATERIALS AND METHODS: Thirty-four patients (mean age, 71 years) with biopsy-proved prostate cancer and known or suspected metastatic disease were examined. Blinded interpretation of the PET images was compared with bone scan, CT, and clinical follow-up findings.RESULTS: In 202 untreated osseous metastases in 22 patients, the sensitivity of FDG PET was 65% (131 of 202 metastases), with a positive predictive value of 98% (131 of 133 positive findings). The estimated standardized uptake value in metastases was 2.1-5.7. Soft-tissue metastases to the lymph nodes or liver were identified, but evaluation of pelvic lymph node metastases was severely limited because of bladder tracer activity.CONCLUSION: FDG PET can help identify osseous and soft-tissue metastases of prostate cancer with a high positive predictive value but is less sensitive than bone scintigraphy in the identification of osseous metastases.