Evaluation of neuroendocrine tumors with 99mTc-EDDA/HYNIC TOC
Evaluation of neuroendocrine tumors with 99mTc-EDDA/HYNIC TOC
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DOI：
10.5603/nmr.2016.0020
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发表时间：
2016-01-01
影响因子：
0.9
通讯作者：
Obradovic, Vladimir
中科院分区：
文献类型：
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作者：
Artiko, Vera;Afgan, Aida;Obradovic, Vladimir
背景技术背景：材料与方法：对495例不同类型的神经内分泌肿瘤进行了研究，结果：真阳性（TP）334例，真阴性（TN）73例，假阳性（FP）6例，假阴性（FN）82例。122例（25%）根据SPECT检查结果作出诊断。TP病例的平均T/NT比值在SPECT上（3.12 +/- 1.13）显著高于全身扫描（2.2 +/- 0.75）（p < 0.01）。根据我们的结果，该方法的总体敏感性为80%，特异性为92%，阳性预测值为98%，阴性预测值为47%，准确性为82%。结论：Tc-Tektrotyd显像对神经内分泌肿瘤的诊断、分期及随访有重要价值。SPECT在诊断中有重要作用。这也有助于治疗方法的选择，包括肽受体放射性核素治疗。在缺乏Ga-68标记肽和PET/CT的情况下，应特别强调SPECT/CT的应用以及放射导向手术。
BACKGROUND: This paper is the short review of our preliminary results obtained with Tc-99m-EDDA/HYNIC-TOC.MATERIAL AND METHODS: The total of 495 patients with different neuroendocrine tumors were investigated during last few years.RESULTS: There have been 334 true positive (TP), 73 true negative (TN), 6 false positive (FP) and 82 false negative findings (FN). Diagnosis was made according to SPECT findings in 122 patients (25%). The mean T/NT ratio for TP cases was significantly higher (p < 0.01) on SPECT (3.12 +/- 1.13) than on whole body scan (2.2 +/- 0.75). According to our results, overall sensitivity of the method is 80%, specificity 92%, positive predictive value 98%, negative predictive value 47% and accuracy 82%. Fifteen TP patients underwent therapy with 90Y-DOTATATE.CONCLUSION: Scintigraphy of neuroendocrine tumors with Tc-99m-Tektrotyd is a useful method for diagnosis, staging and follow up of the patients suspected to have neuroendocrine tumors. SPECT had important role in diagnosis. It is also helpful in the appropriate choice of the therapy, including the peptide receptor radionuclide therapy. In the absence of Ga-68-labeled peptides and PET/CT, the special emphasize should be given to application of SPECT/CT as well as to the radioguided surgery.