Socioeconomic status is independently associated with overall survival in patients with multiple myeloma.
Socioeconomic status is independently associated with overall survival in patients with multiple myeloma.
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DOI：
10.3109/10428194.2015.1011156
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发表时间：
2015
影响因子：
2.6
通讯作者：
Wildes TM
中科院分区：
文献类型：
--
作者：
Fiala MA;Finney JD;Liu J;Stockerl-Goldstein KE;Tomasson MH;Vij R;Wildes TM
基于人群的研究表明，多发性骨髓瘤（MM）黑人患者的死亡率高于白色患者;然而，其他研究表明，这种差异与社会经济地位（SES）而不是种族有关。为了澄清这一主题，我们回顾了我们机构诊断为MM的562例患者。高SES患者的中位OS为62.8个月（mos）（95% CI 43.1-82.6 mos），而中SES和低SES患者的中位OS分别为53.7个月（45.2-62.3 mos）和48.6个月（40.4-56.8 mos）（p =0.015）。在控制了种族、年龄、诊断年份、合并症的严重程度、干细胞移植利用率和保险提供者之后，低SES患者的死亡率相对于高SES患者增加了54%。为了支持我们的研究结果，我们对来自监测流行病学和最终结果-18（SEER）数据库的45，505例MM患者进行了类似的分析。低SES与MM的OS较差独立相关。
Population-based studies suggest that black patients with multiple myeloma (MM) have a higher mortality rate than white patients; however, other studies suggest this disparity is related to socioeconomic status (SES) rather than race. To provide clarity on this topic, we reviewed 562 patients diagnosed with MM at our institution. Patients with high-SES had a median OS of 62.8 months (mos) (95% CI 43.1–82.6 mos), compared to 53.7 mos (45.2–62.3 mos) and 48.6 mos (40.4–56.8 mos) for the middle and low-SES, respectively (p =0.015). After controlling for race, age, year of diagnosis, severity of comorbidities, stem cell transplant utilization, and insurance provider, patients with low-SES had a 54 percent increase in mortality rate relative to patients with high-SES. To support our findings, we performed a similar analysis of 45,505 patients with MM from the Surveillance Epidemiology and End Results-18 (SEER) database. Low-SES is independently associated with poorer OS in MM.