Early Clinical and Laboratory Diagnosis of Invasive Pulmonary, Extrapulmonary, and Disseminated Mucormycosis (Zygomycosis)
Early Clinical and Laboratory Diagnosis of Invasive Pulmonary, Extrapulmonary, and Disseminated Mucormycosis (Zygomycosis)
复制标题
DOI：
10.1093/cid/cir868
复制
发表时间：
2012-02-01
影响因子：
11.8
通讯作者：
Kontoyiannis, Dimitrios P.
中科院分区：
文献类型：
--
作者：
Walsh, Thomas J.;Gamaletsou, Maria N.;Kontoyiannis, Dimitrios P.
侵袭性毛霉菌病的早期诊断对于及时治疗干预、提高生存率和降低发病率非常重要。鉴于侵袭性毛霉菌病的准确和快速诊断的重要性，指导及时启动阿替霉素B和可能的手术干预，一个协调的多学科方法的临床评估，诊断成像和实验室评估是必要的。毛霉菌病的实验室评估包括直接检查和组织培养、呼吸道分泌物、支气管肺泡灌洗液和其他液体的常规方法。然而，由于传统的诊断工具是有限的，在他们的灵敏度，先进的分子扩增系统，抗原检测分析，蛋白质组学谱和代谢产物检测可以补充现有的方法，以提高侵袭性毛霉菌病的早期诊断率。
Early diagnosis of invasive mucormycosis is important for timely therapeutic intervention, improved survival, and reduced morbidity. Given the importance of an accurate and rapid diagnosis of invasive mucormycosis to guide the timely initiation of amphotericin B and possible surgical intervention, a coordinated multidisciplinary approach of clinical assessment, diagnostic imaging, and laboratory assessment is necessary. Laboratory assessment for mucormycosis includes the conventional methods of direct examination and culture of tissue, respiratory secretions, bronchoalveolar lavage fluid, and other fluids. However, because conventional diagnostic tools are limited in their sensitivity, advanced molecular amplification systems, antigen detection assays, proteomic profiles, and metabolite detection may complement existing approaches to improve the rate of early diagnosis of invasive mucormycosis.