Impacts of Metabolic Syndrome Scores on Cerebrovascular Conductance Are Mediated by Arterial Stiffening.
Impacts of Metabolic Syndrome Scores on Cerebrovascular Conductance Are Mediated by Arterial Stiffening.
复制标题
代谢综合征评分对脑血管电导的影响是由动脉硬化介导的。
DOI：
10.1093/ajh/hpx132
复制
发表时间：
2017
影响因子：
3.2
通讯作者：
Tanaka,Hirofumi
中科院分区：
文献类型：
--
作者：
Pasha,EvanP;Birdsill,AlexC;Oleson,Stephanie;Haley,AndreanaP;Tanaka,Hirofumi
背景代谢综合征(METS)个体表现为脑血流量减少。这种减少的机制尚不清楚，但动脉硬化已被认为是一个因素。我们确定蛋氨酸是否与中年时脑血流量减少有关，如果是，动脉僵硬是否起调节作用。方法对83名中年(40-60岁)社区成年人进行研究。计算每个受试者的METS分数。经颅多普勒超声检测大脑中动脉血流动力学变化。结果受试者存在亚临床METS病理(METS评分=19 8±10 4)，与脑血管传导呈负相关(CVC：r=−0.261，P=0 0 2)。颈动脉-股动脉脉搏波速度(r=−0.188，P=0.0 9)、臂踝脉搏波速度(r=−0.161，P=0.15)和颈动脉扩张性(r=−0.10，P=0.37)排除了METS评分与CVC的直接关联，显示了完全中介作用。非参数自举进一步显示cfPWV、baPWV和颈动脉扩张性的显著间接影响，完全调节临床下蛋氨酸所致的CVC的减少。颈动脉扩张性对下腔静脉的影响最大(B=−0.0019，SE=0.0012，−0.0050~−0.0002 95%可信区间)。
BACKGROUNDIndividuals with metabolic syndrome (MetS) exhibit reduced cerebral blood flow. The mechanisms of this reduction remain unknown but arterial stiffening has been implicated as a contributor. We determined if MetS was associated with reduced cerebral blood flow at midlife, and if so, whether arterial stiffness was responsible for mediating their relation.METHODSMiddle-aged (40–60 years) community dwelling adults (n= 83) were studied. MetS score was calculated for each subject. Middle cerebral artery hemodynamics was measured using transcranial Doppler ultrasound. Indices of aortic, systemic, and carotid artery stiffness were derived.RESULTSSubjects had subclinical MetS pathology (MetS score = 19.8 ± 10.4) that was inversely associated with cerebrovascular conductance (CVC:r= −0.261,P= 0.02). Carotid-femoral pulse wave velocity (cfPWV) (r= −0.188,P= 0.09), brachial-ankle pulse wave velocity (baPWV) (r= −0.161,P= 0.15), and carotid artery distensibility (r= −0.10,P= 0.37) abrogated the direct association of MetS score and CVC, demonstrating full mediation. Nonparametric bootstrapping further indicated significant indirect effects of cfPWV, baPWV, and carotid artery distensibility, fully mediating reductions of CVC exerted from sublcinical MetS. Carotid artery distensibility demonstrated the greatest effect on CVC (B= −0.0019, SE = 0.0012, −0.0050 to −0.0002 95% confidence interval).CONCLUSIONSArterial stiffness, particularly the stiffness of the carotid artery, mediated reductions in CVC related to MetS.