Helicobacter pylori Seroprevalence in Symptomatic Veterans: A Study of 7310 Patients Over 11 Years
Helicobacter pylori Seroprevalence in Symptomatic Veterans: A Study of 7310 Patients Over 11 Years
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DOI：
10.1111/j.1523-5378.2009.00693.x
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发表时间：
2009-08-01
期刊：
影响因子：
4.4
通讯作者：
Genta, Robert M.
中科院分区：
文献类型：
--
作者：
Carmack, Susanne W.;Genta, Robert M.
背景和目的：美国幽门螺杆菌感染的患病率一直在下降，但缺乏最新数据。本研究评估了抗幽门螺旋杆菌的血清阳性率。在过去 11 年中对有症状的退伍军人进行了幽门螺杆菌抗体检测。 材料和方法：相同的血清抗幽门螺杆菌抗体。自 1996 年底以来，一家三级护理退伍军人事务医院开始使用幽门螺杆菌 IgG 检测系统。对 1997 年至 2007 年进行的所有检测结果进行了分析。结果：在 7310 名接受检测的患者中，3982 名 (54.5%) 呈阳性。血清阳性率从1997年的70.8%下降到2002年的48.6%，然后稳定在50%左右。存在很强的出生队列效应，1920 年之前出生的退伍军人的血清阳性率为 72.7%，1980 年之后出生的退伍军人的血清阳性率为 22%。结论：尽管出生队列效应持续存在，但有症状的退伍军人中幽门螺杆菌血清阳性率在 1997 年至 2002 年稳步下降后，降至 50% 左右。
Background and Aims: The prevalence of Helicobacter pylori infection has been decreasing in the USA, but recent data are lacking. This study evaluates the seroprevalence for anti-H. pylori antibodies in symptomatic veterans tested over the past 11 years.Materials and Methods: The same serum anti-H. pylori IgG detection system has been used at a tertiary care Veterans Affairs hospital since late 1996. Results of all tests performed from 1997 to 2007 were analyzed.Results: Of 7310 unique patients tested, 3982 (54.5%) were positive. Seropositivity declined from 70.8% in 1997 to 48.6% in 2002, then reached a plateau around 50%. A strong birth cohort effect was present, from a seropositivity of 72.7% for the veterans born before 1920 to 22% for those born between after 1980.Conclusions: Despite a constant birth cohort effect, H. pylori seropositivity among symptomatic veterans leveled down at similar to 50% after declining steadily from 1997 to 2002.