Minimal vascular flows cause strong heat sink effects in hepatic radiofrequency ablation ex vivo
Minimal vascular flows cause strong heat sink effects in hepatic radiofrequency ablation ex vivo
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DOI：
10.1002/jhbp.370
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发表时间：
2016-08-01
影响因子：
3
通讯作者：
Zurbuchen, Urte
中科院分区：
文献类型：
--
作者：
Lehmann, Kai S.;Poch, Franz G. M.;Zurbuchen, Urte
BackgroundThe本论文旨在评估血管流速的下限对离体双极射频消融（RFA）热沉效应的影响。方法将内径为3.4mm的玻璃管（血管）平行于双极RFA施加器引入离体猪肝。血管灌注流速0 ~ 1，500 ml/min，射频消融（功率30 W，能量输入15 kJ）在室温和37 ℃下进行。热沉的影响进行了评估，在射频消融截面的消融半径，面积和高分辨率的扇区planimetry.ResultsFlow率为1 ml/min的减少已经造成了显着的冷却效果（P 0.001）。在10 ml/min（18.4mm/s）时，热沉效应达到最大值，并在1, 500 ml/min的流速下保持稳定。ConclusionsMinimum vascular flows of 1 ml/min在离体肝RFA中引起显著的热沉效应。未发现体积流速的下限。在流速为10 ml/min时，热沉效应达到最大值，并在流速高达1，500 ml/min时保持稳定。在靠近肝血管的RFA中，应考虑肝流入阻断。
BackgroundThe present paper aims to assess the lower threshold of vascular flow rate on the heat sink effect in bipolar radiofrequency ablation (RFA) ex vivo.MethodsGlass tubes (vessels) of 3.4mm inner diameter were introduced in parallel to bipolar RFA applicators into porcine liver ex vivo. Vessels were perfused with flow rates of 0 to 1,500ml/min. RFA (30W power, 15kJ energy input) was carried out at room temperature and 37 degrees C. Heat sink effects were assessed in RFA cross sections by the decrease in ablation radius, area and by a high-resolution sector planimetry.ResultsFlow rates of 1ml/min already caused a significant cooling effect (P0.001). The heat sink effect reached a maximum at 10ml/min (18.4mm/s) and remained stable for flow rates up to 1,500ml/min.ConclusionsMinimal vascular flows of 1ml/min cause a significant heat sink effect in hepatic RFA ex vivo. A lower limit for volumetric flow rate was not found. The maximum of the heat sink effect was reached at a flow rate of 10ml/min and remained stable for flow rates up to 1,500ml/min. Hepatic inflow occlusion should be considered in RFA close to hepatic vessels.