FAMILY PATTERNS OF CORONARY HEART-DISEASE MORTALITY - THE FRAMINGHAM LONGEVITY STUDY
FAMILY PATTERNS OF CORONARY HEART-DISEASE MORTALITY - THE FRAMINGHAM LONGEVITY STUDY
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DOI：
10.1016/0895-4356(92)90009-c
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发表时间：
1992-02-01
影响因子：
7.2
通讯作者：
MYERS, RH
中科院分区：
文献类型：
--
作者：
BRAND, FN;KIELY, DK;MYERS, RH
在弗雷明汉研究中，研究人员对5209名男性和女性（2900名死者，2309名在世者）及其父母进行了40年的随访，研究了他们死亡时的家庭模式。母亲和父亲死亡时的年龄都明显大于存活后代（p < 0.0001）。当根据后代的死亡原因评估寿命时，父母死亡时的年龄是冠状动脉心脏病（CHD）死亡的重要预测因子，但不是中风或癌症的预测因子。对突发性冠心病死亡子代的多元回归分析显示，母亲死亡年龄是突发性冠心病死亡年龄的显著预测因子（p < 0.0003），而父亲死亡年龄是非突发性冠心病死亡年龄的显著预测因子（p < 0.004）。生命表分析显示，父母双方都活到75岁或以上的人的存活率最长，其次是母亲只活到75岁或以上的人，然后是父亲只活到75岁的人，而父母都活不到75岁的人的存活率最短。寿命与母亲死亡年龄的关系似乎比与父母死亡年龄的关系更密切。与冠心病相关的危险因素的比例风险分析显示，收缩压、个体性别和吸烟是死亡年龄最显著的预测因素。这些发现表明，死亡年龄的家族相似性可能主要是通过家族内共同的冠心病危险因素介导的，无论是遗传的还是非遗传的。
Family patterns for age at death were examined in a 40 year follow-up of 5209 men and women (2900 deceased, 2309 living) in the Framingham Study and their parents. Age at death of both mothers and fathers was significantly older for surviving offspring when compared to decreased offspring (p < 0.0001). When longevity was assessed according to cause of death in the offspring, parental age at death was a significant predictor of death by coronary heart disease (CHD), but not for stroke or cancer. Multiple regression analysis for offspring with sudden CHD death revealed that mother's age at death was a significant predictor of age at sudden CHD death (p < 0.0003) whereas father's age at death was a significant predictor of age at death in non-sudden CHD death (p < 0.004). Life table analysis showed longest survival rates associated with both parents surviving to age 75 or older followed by mother only surviving to age 75 or older, then father only, and shortest survival with neither parent surviving to age 75. Longevity appears to be more strongly associated with maternal death age than parental death age. Proportional hazards analysis of risk factors associated with CHD revealed that systolic blood pressure, sex of the individual, and cigarette smoking were the most significant predictors of death age. These findings suggest that familial similarities for death age may be mediated primarily through shared CHD risk factors within families, either genetic or non-genetic.