DIFFERENCES IN BIOLOGIC MATURATION, SEXUAL-BEHAVIOR, AND SEXUALLY-TRANSMITTED DISEASE BETWEEN ADOLESCENTS WITH AND WITHOUT CERVICAL INTRAEPITHELIAL NEOPLASIA
DIFFERENCES IN BIOLOGIC MATURATION, SEXUAL-BEHAVIOR, AND SEXUALLY-TRANSMITTED DISEASE BETWEEN ADOLESCENTS WITH AND WITHOUT CERVICAL INTRAEPITHELIAL NEOPLASIA
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DOI：
10.1016/s0022-3476(89)80863-7
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发表时间：
1989-09-01
影响因子：
5.1
通讯作者：
SCHACHTER, J
中科院分区：
文献类型：
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作者：
MOSCICKI, AB;WINKLER, B;SCHACHTER, J
由于几个辅助因子可能影响年轻女性宫颈上皮内瘤变（CIN）的发展，我们比较了行为的差异，（性活动、避孕和吸烟）、性传播疾病（STD）感染率（沙眼衣原体、淋病奈瑟菌、阴道毛滴虫和单纯疱疹病毒），和宫颈成熟（月经初潮年龄和宫颈异位百分比）在有和无CIN的性活跃女性青少年组。将CIN患者与三个非CIN组进行比较：（1）被转诊到青少年阴道镜诊所但没有CIN证据的青少年（高危组），（2）在妇科诊所没有性病症状的青少年（无症状组），以及（3）在妇科诊所有性病症状的青少年（有症状组）。通过阴道摄影测量宫颈异位的百分比。CIN患者比无症状组有更多的终生性伴侣（p < 0.001），比妇科门诊组更可能吸烟（p < 0.01）。CIN组与高危组之间的行为无差异。CIN组月经初潮平均年龄比非CIN组大1岁（p < 0.05），异位面积大于非CIN组（p < 0.02）。CIN患者更有可能有C的既往史或现病史。沙眼感染率高于两个妇科门诊组：CIN组与高危组之间无差异。我们的结论是吸烟、性乱和C。沙眼感染可能影响宫颈脆弱性。然而，宫颈生物学不成熟是青春期女孩发生CIN的重要危险因素。
Because several cofactors may influence the development of cervical intraepithelial neoplasia (CIN) in young women, we compared differences in behaviors (sexual activity, contraception, and cigarette use), sexually transmitted disease (STD) infection rates (Chiamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and herpes simplex virus), and cervical maturation (age of menarch and percentage of cervical ectopy) in groups of sexually active female adolescents with and without CIN. Those with CIN were compared with three non-CIN groups: (1) teenagers who were referred to a teen colposcopy clinic but had no evidence of CIN (high risk group), (2) teenagers seen at a gynecology clinic without STD symptoms (asymptomatic group), and (3) teenagers seen in the gynecology clinic with STD symptoms (symptomatic group). The percentage of cervical ectopy was measured by colpophotography. Subjects with CIN had more lifetime sexual partners than the asymptomatic group (p < 0.001) and were more likely to smoke cigarettes than either gynecology clinic group (p < 0.01). No differences in behaviors existed between the CIN and high-risk groups. The mean age of menarche in those with CIN was 1 year older than all three non-CIN groups (p < 0.05), and those with CIN had a greater area of ectopy than those without CIN (p < 0.02). Those with CIN were more likely to have a past or present history of C. trachomatis infection than the two gynecology clinic groups: no difference was found between the CIN and high-risk groups. We conclude that cofactors such as smoking, sexual promiscuity, and C. trachomatis infection may influence cervical vulnerability. However, cervical biologic immaturity is an important risk factor for development of CIN in adolescent girls.