Wall shear stress is lower in the carotid artery responsible for a unilateral ischemic stroke
Wall shear stress is lower in the carotid artery responsible for a unilateral ischemic stroke
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DOI：
10.1016/j.atherosclerosis.2005.05.019
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发表时间：
2006-03-01
期刊：
影响因子：
5.3
通讯作者：
de Franceschi, MS
中科院分区：
文献类型：
--
作者：
Carallo, C;Lucca, LF;de Franceschi, MS
根据动脉粥样硬化的局灶性性质，缺血性卒中常常是单侧的。动脉粥样硬化斑块受到局部血流动力学因素的影响，例如低壁切应力和/或周壁张力升高。本研究的目的是探讨血流动力学与脑血管疾病之间的可能联系。对25例近期单侧大动脉卒中伴颈动脉非狭窄斑块的患者（大动脉组）和10例近期单侧心源性栓塞性卒中不伴颈动脉斑块的患者（心源性栓塞组）的颈总动脉平均壁剪切应力和周向壁张力、Peterson弹性模量和血流量进行了测量。在大动脉组中，动脉粥样硬化在脑缺血侧稍微更明显。所有血流动力学因素在该组患侧更不利（剪切应力：6.2 +/- 3.0与8.6 +/- 4.0达因/cm（2），p < 0.0001;壁张力：（7.3 +/- 1.3）x 10（4）与（6.6 +/- 1.3）× 10（4）达因/cm，p < 0.00001;彼得森模量：（16.8 +/- 11.9）× 10（5）对比（12.4 +/- 5.7）× 10（5）达因/cm（2），p = 0.06）。心源性栓塞组与对照组相比，血流无明显差异。目前的数据表明，不利的血流动力学资料在颈总动脉供应的面积一个单一的大动脉中风，并可能有助于解释这种疾病的频繁片面性。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
According to the focal nature of atherosclerosis, ischemic stroke is frequently unilateral. Atherosclerotic plaques are favoured by local hemodynamic factors as low wall shear stress and/or elevated circumferential wall tension. Aim of the present study was to investigate the possible association between hemodynamic forces and cerebrovascular disease. Common carotid mean wall shear stress and circumferential wall tension, Peterson's elastic modulus, and blood flow were measured in 25 patients with a recent unilateral large-artery stroke presenting non-stenotic plaques of the carotid arteries (large-artery group), and in 10 patients affected by a recent unilateral cardioembolic stroke without carotid plaques (cardioembolic group). In the large-artery group, atherosclerosis was slightly more evident in the side of cerebral ischemia. All hemodynamic factors were more unfavourable at the affected side in this group (shear stress: 6.2 +/- 3.0 versus 8.6 +/- 4.0 dynes/cm(2), p < 0.0001; wall tension: (7.3 +/- 1.3) x 10(4) versus (6.6 +/- 1.3) x 10(4) dynes/cm, p < 0.00001; Peterson's modulus: (16.8 +/- 11.9) x 10(5) versus (12.4 +/- 5.7) x 10(5) dynes/cm(2), p = 0.06). No difference was detectable in blood flow and in cardioembolic group. The present data demonstrate an unfavourable hemodynamic profile in the common carotid artery supplying the area of a single large-artery stroke and might help to explain the frequent one-sidedness of this disease. (c) 2005 Elsevier Ireland Ltd. All rights reserved.