PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion
PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion
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DOI：
10.1128/jvi.01177-06
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发表时间：
2006-11-01
影响因子：
5.4
通讯作者：
Ferrari, Carlo
中科院分区：
文献类型：
--
作者：
Urbani, Simona;Amadei, Barbara;Ferrari, Carlo
丙型肝炎病毒（HCV）特异性CD 8细胞耗竭可能代表了HCV持续存在的机制。据报道，抑制性受体PD-1在耗尽的CD 8细胞中上调。因此，我们纵向研究了PD-1在急性HCV感染期间的表达。大多数HCV特异性CD 8细胞在急性疾病时表达PD-1，无论最终结果如何。PD-1表达随着记忆表型的获得和有效的CD 8细胞功能在解决HCV感染中的恢复而下降，而当HCV持续存在且HCV特异性CD 8细胞仍然功能障碍时，PD-1表达保持高水平。用抗PDL-1抗体阻断PD-1/PDL-1相互作用改善了病毒特异性CD 8细胞的扩增能力。
Hepatitis C virus (HCV)-specific CD8 cell exhaustion may represent a mechanism of HCV persistence. The inhibitory receptor PD-1 has been reported to be up-regulated in exhausted CD8 cells. Therefore, we studied PD-1 expression longitudinally during acute HCV infection. Most HCV-specific CD8 cells expressed PD-1 at the time of acute illness, irrespective of the final outcome. PD-1 expression declined with the acquisition of a memory phenotype and recovery of an efficient CD8 cell function in resolving HCV infections, whereas high levels were maintained when HCV persisted and HCV-specific CD8 cells remained dysfunctional. Blocking PD-1/PDL-1 interaction with an anti-PDL-1 antibody improved the capacity of expansion of virus-specific CD8 cells.