OPENING MECHANISMS OF THE HUMAN UPPER ESOPHAGEAL SPHINCTER
OPENING MECHANISMS OF THE HUMAN UPPER ESOPHAGEAL SPHINCTER
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DOI：
10.1152/ajpgi.1989.257.5.g748
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发表时间：
1989-11-01
影响因子：
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通讯作者：
HOGAN, WJ
中科院分区：
文献类型：
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作者：
COOK, IJ;DODDS, WJ;HOGAN, WJ
本研究的目的是评估吞咽相关的食管上括约肌开口（UES）的作用机制，并确定液体流过括约肌的动力学。为此，我们同时对15名正常受试者进行了2- 30ml钡剂摄食和测压研究。我们发现静息的UES高压区与环咽部的位置紧密对应。结果表明，压力测量UES松弛和喉前舌骨牵引总是在UES打开之前。随着剂量的逐渐增加，UES直径、横截面积、血流持续时间和经括约肌流速逐渐增加。经括约肌流钡时，UES上游和UES开口处的肠内压力保持在狭窄的生理范围内
Our goals in this study were to evaluate the mechanisms operative in swallow-associated opening of the upper esophageal sphincter (UES) and to determine the dynamics of fluid flow across the sphincter. For this purpose, we obtained concurrent videofluorographic and manometric studies of 2- to 30-ml barium swallows in 15 normal subjects. We found that the resting UES high-pressure zone corresponded closely with the location of the cricopharyngeus. The findings indicated that manometric UES relaxation and anterior hyoid traction on the larynx invariably preceded UES opening. With graded increases in bolus volume, progressive increases occurred in UES diameter, cross-sectional area, flow duration, and transsphincteric flow rate. Intrabolus pressure upstream to the UES and within the UES at its opening during transsphincteric flow of barium remained within a narrow physiological range of