Laboratory-based surveillance and molecular epidemiology of influenza virus in Taiwan
Laboratory-based surveillance and molecular epidemiology of influenza virus in Taiwan
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DOI：
10.1128/jcm.43.4.1651-1661.2005
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发表时间：
2005-04-01
影响因子：
9.4
通讯作者：
Su, IJ
中科院分区：
文献类型：
--
作者：
Shih, SR;Chen, GW;Su, IJ
在台湾疾病预防控制中心 (CDC) 的协调下，台湾建立了由 11 个临床病毒学实验室组成的流感病毒实验室监测网络。 2000年10月至2004年3月，分离出3,244种流感病毒，其中甲型流感病毒1,969种，乙型流感病毒1,275种。北半球冬季流感感染多发。然而，在调查的四个季节中，台湾的流感季节性并不明显。例如，甲型流感病毒在2001年、2002年和2003年的冬季出现高峰。然而，在2001年和2002年的夏季和秋季（6月至11月）也发现了一些孤立的高峰。乙型流感病毒的异常高峰也出现在2002年夏季（6月至8月）。系统发育分析表明，同一年的甲型流感病毒分离株经常被归为一组。然而，2002年的乙型流感病毒分离物聚集成不同的组，并且数据表明B/Victoria/2/87样和B/Yamagata/16/88样B型流感病毒谱系同时循环。流行毒株与疫苗毒株的序列比较显示，许多类似疫苗的台湾毒株在疫苗毒株推出之前至少已经传播了两年。与其他大陆地区相比，台湾的流感报告没有明显的季节性。
A laboratory-based surveillance network of 11 clinical virological laboratories for influenza viruses was established in Taiwan under the coordination of the Center for Disease Control and Prevention (CDC), Taiwan. From October 2000 to March 2004, 3,244 influenza viruses were isolated, including 1,969 influenza A and 1,275 influenza B viruses. The influenza infections usually occurred frequently in winter in the northern hemisphere. However, the influenza seasonality in Taiwan was not clear during the four seasons under investigation. For example, the influenza A viruses peaked during the winters of 2001, 2002, and 2003. However, some isolated peaks were also found in the summer and fall (June to November) of 2001 and 2002. An unusual peak of influenza B also occurred in the summer of 2002 (June to August). Phylogenetic analysis shows that influenza A isolates from the same year were often grouped together. However, influenza B isolates from the year 2002 clustered into different groups, and the data indicate that both B/Victoria/2/87-like and B/Yamagata/ 16/88-like lineages of influenza B viruses were cocirculating. Sequence comparison of epidemic strains versus vaccine strains shows that many vaccine-like Taiwanese strains were circulating at least 2 years before the vaccine strains were introduced. No clear seasonality of influenza reports in Taiwan occurred in contrast to other more continental regions.