Type 2 Innate Lymphoid Cells in Allergic Disease.
Type 2 Innate Lymphoid Cells in Allergic Disease.
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DOI：
10.2174/1573395510666140304235916
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发表时间：
2013-11
影响因子：
--
通讯作者：
Doherty TA
中科院分区：
文献类型：
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作者：
Lund S;Walford HH;Doherty TA
II型先天性淋巴样细胞（ILC 2）是一种新的谱系阴性细胞群体，其产生高水平的Th 2细胞因子IL-5和IL-13。ILC 2存在于人呼吸道和胃肠道组织以及皮肤中。来自哮喘和特应性皮炎小鼠模型的研究表明ILC 2在促进过敏性炎症中的作用。上皮细胞因子IL-25、IL-33和TSLP以及脂质介质白三烯D4已显示在特定条件下有效激活ILC 2，并支持过敏性疾病中许多单独的途径可能导致ILC 2刺激的观点。需要进行持续的研究以更好地表征ILC 2在过敏性炎症中的相对贡献以及其他细胞类型（包括常规T细胞）调节ILC 2存活、增殖和细胞因子产生的机制。重要的是，靶向ILC 2的治疗策略可以减少患病个体的过敏性炎症。本文综述了ILC 2的发展、表面标志物、细胞因子的产生及其上游调控，并重点介绍了ILC 2在常见过敏性疾病中的作用。
Type II innate lymphoid cells (ILC2) are a novel population of lineage-negative cells that produce high levels of Th2 cytokines IL-5 and IL-13. ILC2 are found in human respiratory and gastrointestinal tissue as well as in skin. Studies from mouse models of asthma and atopic dermatitis suggest a role for ILC2 in promoting allergic inflammation. The epithelial cytokines IL-25, IL-33, and TSLP, as well as the lipid mediator leukotriene D4, have been shown to potently activate ILC2 under specific conditions and supporting the notion that many separate pathways in allergic disease may result in stimulation of ILC2. Ongoing investigations are required to better characterize the relative contribution of ILC2 in allergic inflammation as well as mechanisms by which other cell types including conventional T cells regulate ILC2 survival, proliferation, and cytokine production. Importantly, therapeutic strategies to target ILC2 may reduce allergic inflammation in afflicted individuals. This review summarizes the development, surface marker profile, cytokine production, and upstream regulation of ILC2, and focuses on the role of ILC2 in common allergic diseases.