The relationship between alcohol consumption and glycemic control among patients with diabetes: The Kaiser Permanente Northern California Diabetes Registry
The relationship between alcohol consumption and glycemic control among patients with diabetes: The Kaiser Permanente Northern California Diabetes Registry
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DOI：
10.1007/s11606-007-0502-z
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发表时间：
2008-03-01
影响因子：
5.7
通讯作者：
Weisner, Constance M.
中科院分区：
文献类型：
--
作者：
Ahmed, Ameena T.;Karter, Andrew J.;Weisner, Constance M.
背景：饮酒是一种常见的行为。目的：评估饮酒和血糖控制之间的关系。设计：对北加州凯撒永久成员进行1994-1997年的调查跟踪研究。患者：38,564名成年糖尿病患者。测量：自调查日期起一年内评估的自我报告的饮酒量和糖化血红蛋白(A1C)。通过饮酒对糖化血红蛋白进行线性回归，并根据社会人口学变量、临床变量和糖尿病疾病严重程度进行调整。结果：在多变量调整模型中，A1C值分别为8.88(终生戒酒者)、8.79(既往饮酒者)、8.90(饮酒0.1次/天)、8.71(0.1-0.9次/天)、8.51(1-1.9次/天)、8.39(2-2.9次/天)和8.47(3次/天)。在糖尿病患者中，饮酒与糖化血红蛋白呈线性相关(p<；0.001)，与糖化血红蛋白呈负相关(p=0.001)。结论：糖尿病患者饮酒与血糖控制呈负相关。这支持了目前糖尿病患者适度饮酒的临床指南。由于血糖控制影响糖尿病并发症的发生率，与适度饮酒相关的较低的A1C水平可能转化为较低的并发症风险。
BACKGROUND: Alcohol consumption is a common behavior. Little is known about the relationship between alcohol consumption and glycemic control among people with diabetes.OBJECTIVE: To evaluate the association between alcohol consumption and glycemic control.DESIGN: Survey follow-up study, 1994-1997, among Kaiser Permanente Northern California members.PATIENTS: 38,564 adult diabetes patients.MEASUREMENTS: Self-reported alcohol consumption, and hemoglobin A1C (A1C), assessed within 1 year of survey date. Linear regression of A1C by alcohol consumption was performed, adjusted for sociodemographic variables, clinical variables, and diabetes disease severity. Least squares means estimates were derived.RESULTS: In multivariate-adjusted models, A1C values were 8.88 (lifetime abstainers), 8.79 (former drinkers), 8.90 (< 0.1 drink/day), 8.71 (0.1-0.9 drink/day), 8.51 (1-1.9 drinks/day), 8.39 (2-2.9 drinks/day), and 8.47 (>= 3 drinks/day). Alcohol consumption was linearly (p < 0.001) and inversely (p=0.001) associated with A1C among diabetes patients.CONCLUSIONS: Alcohol consumption is inversely associated with glycemic control among diabetes patients. This supports current clinical guidelines for moderate levels of alcohol consumption among diabetes patients. As glycemic control affects incidence of complications of diabetes, the lower A1C levels associated with moderate alcohol consumption may translate into lower risk for complications.