The Neurotoxicity of 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine in the Monkey and Man
The Neurotoxicity of 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine in the Monkey and Man
复制标题
1-甲基-4-苯基-1,2,3,6-四氢吡啶对猴和人的神经毒性
DOI：
10.1017/s0317167100046345
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
C. Chiueh
中科院分区：
文献类型：
--
作者：
R. Stanley Burns;S. Markey;Jere M. Phillips;C. Chiueh
ABSTRACT l-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) selectively destroys dopaminergic neurons in the pars compacta of the substantia nigra (A8 and A9 cells). MPTP or its metabolite enters nerve cells at the level of their terminals in the caudate nucleus and putamen leading to a disturbance in axoplasmic flow and retrograde degeneration. The species-dependent neurotoxicity of MPTP (primate vs. rodent) suggests that a biochemical property of the cell related to neuromelanin may be important in the mechanism of cell injury.
