Duration of neurofibrillary changes in the hippocampal pyramidal neurons
Duration of neurofibrillary changes in the hippocampal pyramidal neurons
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DOI：
10.1016/s0006-8993(98)00441-7
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发表时间：
1998-07-13
期刊：
影响因子：
2.9
通讯作者：
Wisniewski, HM
中科院分区：
文献类型：
--
作者：
Bobinski, M;Wegiel, J;Wisniewski, HM
对16例Alzheimer病（AD）患者海马CA 1 ~ CA 4区、海马下托和齿状回神经元数量进行了观察。根据AD持续时间与神经元数量之间的回归关系计算神经元数量变化的持续时间。在CA 1和下托中，受神经病理学影响的完整神经元分别需要3.4年和5.4年才能变成鬼缠结。(C)1998 Elsevier Science B. V.保留所有权利。
The total number of neurons with and without neurofibrillary changes in sectors CA1 to CA4, subiculum, and dentate gyrus of 16 subjects with Alzheimer disease (AD) was estimated. The duration of neurofibrillary changes was calculated on the basis of regressions between the duration of AD and neuronal numbers. In the CA1 and subiculum, it takes 3.4 and 5.4 years, respectively, for an intact neuron affected by neurofibrillary pathology to become a ghost tangle. (C) 1998 Elsevier Science B.V. All rights reserved.