Chemical composition of the volatile oil from Cynanchum stauntonii and its activities of anti-influenza virus.
Chemical composition of the volatile oil from Cynanchum stauntonii and its activities of anti-influenza virus.
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DOI：
10.1016/j.colsurfb.2005.05.003
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发表时间：
2005-07
期刊：
影响因子：
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通讯作者：
Yang Zai-chang;Wang Bo-chu;Yang Xiao-sheng;W. Qiang
中科院分区：
文献类型：
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作者：
Yang Zai-chang;Wang Bo-chu;Yang Xiao-sheng;W. Qiang
采用气相色谱-质谱联用技术（GC-MS）测定了水仙根挥发油的含量。鉴定出38种成分。（E，E）-2,4-十烯二醛，3-乙基-4-甲基戊醇，5-戊基-3H-呋喃-2- 1，（E，Z）-2,4-十烯二醛和2(3H)-呋喃酮，二氢-5-戊基是主要成分。挥发油体外抗流感病毒活性（ic50 =64μg/ml）。在体内实验中，它以剂量依赖的方式阻止流感病毒引起的死亡。
The volatile oil of the roots of Cynanchum stauntonii was examined by gas chromatography–mass spectrometry (GC–MS). Thirty-eight constituents were identified. (E,E)-2,4-Decadienal, 3-efhyl-4-methypentanol, 5-pentyl-3H-furan-2-one, (E,Z)-2,4-decadienal and 2(3H)-furanone,dihydro-5-pentyl were found to be the major components. The volatile oil exhibited the activities against influenza virus in vitro (IC50s=64μg/ml). In in vivo experiment, it prevented influenza virus-induced deaths in a dose-dependent manner.