Frontal glucose hypometabolism in abstinent methamphetamine users
Frontal glucose hypometabolism in abstinent methamphetamine users
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DOI：
10.1038/sj.npp.1300699
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发表时间：
2005-07-01
影响因子：
7.6
通讯作者：
Renshaw, PF
中科院分区：
文献类型：
--
作者：
Kim, SJ;Lyoo, IK;Renshaw, PF
探讨了戒除甲基苯丙胺（MA）使用者的相对区域脑葡萄糖代谢（rCMRglc）的变化及其潜在的性别差异。通过 F-18-氟脱氧葡萄糖正电子发射断层扫描测量的相对 rCMRglc，以及通过威斯康星卡片分类测试 (WCST) 评估的额叶执行功能，在 35 名戒断 MA 使用者和 21 名健康对照受试者之间进行了比较。此外，还对男性和女性 MA 用户及其性别匹配的比较对象进行了比较，以调查潜在的性别差异。与健康对照受试者相比，MA 用户右上额叶白质中的 rCMRglc 水平较低，并且 WCST 中的坚持和非坚持错误较多。 MA 用户额叶白质中的相对 rCMRglc 与 WCST 中的错误数量相关。在性别差异的子分析中，相对于性别匹配的比较对象，仅在男性 MA 用户中发现额叶白质中较低的 rCMRglc 和更多 WCST 错误，而在女性 MA 用户中则没有发现。目前的研究结果表明，MA 的使用会导致额叶白质持续代谢低下，并损害额叶执行功能。我们的研究结果还表明，MA 对大脑额叶的神经毒性作用在男性中可能比女性更明显。
Changes in relative regional cerebral glucose metabolism (rCMRglc) and their potential gender differences in abstinent methamphetamine ( MA) users were explored. Relative rCMRglc, as measured by F-18-fluorodeoxyglucose positron emission tomography, and frontal executive functions, as assessed by Wisconsin card sorting test ( WCST), were compared between 35 abstinent MA users and 21 healthy comparison subjects. In addition, male and female MA users and their gender-matched comparison subjects were compared to investigate potential gender differences. MA users had lower rCMRglc levels in the right superior frontal white matter and more perseveration and nonperseveration errors in the WCST, relative to healthy comparison subjects. Relative rCMRglc in the frontal white matter correlated with number of errors in the WCST in MA users. In the subanalysis for gender differences, lower rCMRglc in the frontal white matter and more errors in the WCST were found only in male MA users, not in female MA users, relative to their gender-matched comparison subjects. The current findings suggest that MA use causes persistent hypometabolism in the frontal white matter and impairment in frontal executive function. Our findings also suggest that the neurotoxic effect of MA on frontal lobes of the brain might be more prominent in men than in women.