Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects
Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects
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DOI：
10.1016/s0026-0495(96)90260-7
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发表时间：
1996-08-01
影响因子：
9.8
通讯作者：
Taylor, R
中科院分区：
文献类型：
--
作者：
Phillips, DIW;Caddy, S;Taylor, R
细胞内甘油三酯（TG）是骨骼肌的重要能量来源。然而，最近的证据表明，如果肌肉含有异常高的TG储存，其对胰岛素的敏感性可能会降低，这可能会导致II型糖尿病。为了验证这一假设，我们测量了27名年龄在47至55岁（平均52岁）的女性的肌肉脂质含量，并将其与葡萄糖耐量、胰岛素抵抗和肌肉胰岛素敏感性相关，这些都是通过糖原合成酶的胰岛素激活来测量的，糖原合成酶是一种胰岛素调节酶，对肌肉中的胰岛素作用具有限速作用。通过肌纤维油红O染色测定的肌肉TG含量和细胞内脂质与糖原合成酶活性呈负相关（分别为r = .43，P = .03和r = -.47，P = .02）。此外，细胞内脂质与胰岛素抵抗综合征的特征相关，包括腰臀比增加（r = .47，P = .01）和空腹非酯化脂肪酸（[NEFA] r = .44，P = .04）。这些数据表明，增加的肌肉TG储存与胰岛素刺激的糖原合酶活性降低有关。细胞内脂肪可能是正常人以及II型糖尿病患者胰岛素抵抗的主要原因。版权所有（C）1996由W.B.桑德斯公司
Intracellular triglyceride (TG) is an important energy source for skeletal muscle. However, recent evidence suggests that if muscle contains abnormally high TG stores its sensitivity to insulin may be reduced, and this could predispose to type II diabetes. To test this hypothesis, we measured muscle lipid content in 27 women aged 47 to 55 years (mean, 52) and related it to their glucose tolerance, insulin resistance, and muscle insulin sensitivity as measured by insulin activation of glycogen synthase, an insulin-regulated enzyme that is rate-limiting for insulin action in muscle. Both muscle TG content and intracellular lipid determined by Oil red O staining of muscle fibers were negatively associated with glycogen synthase activation (r = .43, P = .03 and r = -.47, P = .02, respectively). In addition, intracellular lipid correlated with features of the insulin resistance syndrome, including an increased waist to hip ratio (r = .47, P = .01) and fasting nonesterified fatty acids ([NEFA] r = .44, P = .04). These data demonstrate that increased muscle TG stores are associated with decreased insulin-stimulated glycogen synthase activity. Intracellular fat may underlie a major part of the insulin resistance in normal subjects, as well as type II diabetics. Copyright (C) 1996 by W.B. Saunders Company