Optical Ring Resonators: A Platform for Biological Sensing Applications
Optical Ring Resonators: A Platform for Biological Sensing Applications
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DOI：
10.4103/jmss.jmss_9_17
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发表时间：
2017-07
影响因子：
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通讯作者：
A. K. Sarkaleh;B. V. Lahijani;H. Saberkari;A. Esmaeeli
中科院分区：
文献类型：
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作者：
A. K. Sarkaleh;B. V. Lahijani;H. Saberkari;A. Esmaeeli
生物化学和遗传学的迅速发展导致用于检测和预防任务的各种医疗仪器的扩展。另一方面，食物安全是关乎公众健康的重要问题。检测生物颗粒的最可靠的工具之一（即，DNA分子和蛋白质）和确定食品的真实性是光环谐振器。通过在光学环形谐振器的外围上沉积目标颗粒的受体聚合物层，可以通过计算环形谐振器的光谱响应的偏移来识别分子的存在。本文主要研究两种结构的光学环形谐振器的性能，（i）全通和（ii）分插谐振器用于传感应用。我们提出了一种新的配置，通过在全通环形谐振器中引入纳米间隙的传感应用。这些谐振器的性能进行了研究，从传感的角度来看。模拟结果，使用有限差分时域范例，揭示了在环形配置中的纳米间隙的存在实现了更高的灵敏度，因此，这种结构更适合于生物传感应用。
Rapid advances in biochemistry and genetics lead to expansion of the various medical instruments for detection and prevention tasks. On the other hand, food safety is an important concern which relates to the public health. One of the most reliable tools to detect bioparticles (i.e., DNA molecules and proteins) and determining the authenticity of food products is the optical ring resonators. By depositing a recipient polymeric layer of target particle on the periphery of an optical ring resonator, it is possible to identify the existence of molecules by calculating the shift in the spectral response of the ring resonators. The main purpose of this paper is to investigate the performance of two structures of optical ring resonators, (i) all-pass and (ii) add-drop resonators for sensing applications. We propose a new configuration for sensing applications by introducing a nanogap in the all-pass ring resonator. The performance of these resonators is studied from sensing point of view. Simulation results, using finite difference time domain paradigm, revealed that the existence of a nanogap in the ring configuration achieves higher amount of sensitivity; thus, this structure is more suitable for biosensing applications.