Human tumor cloning assay: clinical applications for ovarian, gastric, pancreatic, and colorectal cancers.
Human tumor cloning assay: clinical applications for ovarian, gastric, pancreatic, and colorectal cancers.
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人类肿瘤克隆测定：卵巢癌、胃癌、胰腺癌和结直肠癌的临床应用。
作者：
Weiss Gb;Von Hoff Dd
：在这项研究中，人类克隆形成测定被用作确定腹膜内给药可能感兴趣的化疗药物的工具。常规药物和研究药物均用于卵巢癌、结直肠癌、胰腺癌和胃癌的治疗。绘制体外响应百分比与体内响应百分比的散点图提供了与观察到的体内抗肿瘤活性的一些临床相关性。此外，还鉴定了在克隆形成测定中观察到剂量反应关系证据的抗癌剂。提供此类证据作为选择可用于腹膜内给药的药物的基础。
: In this investigation, the human clonogenic assay is used as a tool to identify which chemotherapeutic agents may be of interest for intraperitoneal administration. Both conventional and investigational agents are examined in ovarian, colorectal, pancreatic, and gastric carcinomas. Scattergrams plotting the in vitro percent response against the in vivo percent response provide some clinical correlation with the observed in vivo antitumor activity. In addition, anticancer agents are identified for which evidence of a dose-response relationship is observed in the clonogenic assay. Such evidence is offered as the basis for the choice of agents that may be useful for intraperitoneal administration.