Lymphadenitis as a major element of disease in the guinea pig model of tuberculosis
Lymphadenitis as a major element of disease in the guinea pig model of tuberculosis
复制标题
DOI：
10.1016/j.tube.2005.11.003
复制
发表时间：
2006-09-01
期刊：
影响因子：
3.2
通讯作者：
Orme, Ian M.
中科院分区：
文献类型：
--
作者：
Basaraba, Randall J.;Dailey, Deanna D.;Orme, Ian M.
小剂量气雾剂感染H37Rv结核分枝杆菌株的豚鼠迅速在肺实质和胸腔内Hitar淋巴结丛内出现肉芽肿性病变。肺部病变不好发于特定的肺叶，病变遍及胸膜下、肺实质和肺实质的血管周围、支气管周围和细支气管周。显著的肺门淋巴结肿大是由于包膜下、皮质旁和髓质肉芽肿性炎症的融合，这些炎症进展到坏死，使正常的淋巴结结构消失。与肺部病变相比，淋巴结病变变得更严重，进展更快。感染前6周接种卡介苗可显著减轻肺和淋巴组织的病变负担，并减少两种组织的坏死进展。卡介苗免疫动物的淋巴结炎症部分消退，取而代之的是成纤维细胞和纤维结缔组织，未免疫动物的白色病变继续进展为坏死。在此，我们讨论了在豚鼠结核气雾化模型中肺和淋巴结病变的分布和进展与儿童自然发生的疾病有相当相似的观察结果。(C)2005爱思唯尔有限公司。保留所有权利。
Guinea pigs infected by low dose aerosol with the H37Rv strain of Mycobocterium tuberculosis rapidly developed granutomatous lesions in the pulmonary parenchyma and within the intra-thoracic hitar lymph node cluster. Lung lesions showed no predilection for specific lobes and were perivascular, peribronchial and peribronchiolar throughout the subpleural, hitar and pulmonary parenchyma. Marked hilar lymph node enlargement was due to coalescing foci of subcapsular, paracortical and medullary granutomatous inflammation that progressed to necrosis that effaced normal lymph node architecture. Lymph node lesions became severe and progressed more rapidly than pulmonary lesions. Immunization with BCG 6 weeks prior to infection significantly reduced the lung and lymph node lesion burden as well as the progression to necrosis in both tissues. Lymph node inflammation in BCG immunized animals partially resolved and was replaced by fibroblasts and fibrous connective tissue white lesions from non-immunized animals continued to progress to necrosis. We discuss here the observation that the distribution and progression of lung and lymph node lesions in the guinea pig aerosol model of tuberculosis have considerable similarity to the naturally occurring disease in children. (c) 2005 Elsevier Ltd. All rights reserved.