Mitigating the risk of African swine fever virus in feed with anti-viral chemical additives
Mitigating the risk of African swine fever virus in feed with anti-viral chemical additives
复制标题
DOI：
10.1111/tbed.13699
复制
发表时间：
2020-07-11
影响因子：
4.3
通讯作者：
Rowland, Raymond R. R.
中科院分区：
文献类型：
--
作者：
Niederwerder, Megan C.;Dee, Scott;Rowland, Raymond R. R.
非洲猪瘟（ASF）目前被认为是全球猪肉生产面临的最大威胁。由ASF病毒（ASFV）引起的疾病导致猪的高病死率。重要的是，非洲猪瘟是一种限制贸易的疾病，对全球猪肉和农业饲料商品都有重大影响。ASFV通过自然食用受污染的猪饲料传播，并且在广泛的常用进口饲料成分和条件下基本稳定。本研究的目的是研究中链脂肪酸和基于甲酰胺的饲料添加剂灭活ASFV的效果。在跨洋运输模型下，对细胞培养物和饲料成分中的饲料添加剂进行了测试。两种化学添加剂均以剂量依赖性方式降低ASFV感染性。这项研究提供的证据表明，化学饲料添加剂可能作为缓解剂，以减少风险的ASFV引入和传播通过饲料。
African swine fever (ASF) is currently considered the most significant global threat to pork production worldwide. Disease caused by the ASF virus (ASFV) results in high case fatality of pigs. Importantly, ASF is a trade-limiting disease with substantial implications on both global pork and agricultural feed commodities. ASFV is transmissible through natural consumption of contaminated swine feed and is broadly stable across a wide range of commonly imported feed ingredients and conditions. The objective of the current study was to investigate the efficacy of medium-chain fatty acid and formaldehyde-based feed additives in inactivating ASFV. Feed additives were tested in cell culture and in feed ingredients under a transoceanic shipment model. Both chemical additives reduced ASFV infectivity in a dose-dependent manner. This study provides evidence that chemical feed additives may potentially serve as mitigants for reducing the risk of ASFV introduction and transmission through feed.