Cullin-RING ubiquitin ligases: global regulation and activation cycles.
Cullin-RING ubiquitin ligases: global regulation and activation cycles.
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DOI：
10.1186/1747-1028-3-7
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发表时间：
2008-02-18
期刊：
影响因子：
2.3
通讯作者：
Kipreos ET
中科院分区：
文献类型：
--
作者：
Bosu DR;Kipreos ET
Cullin-RING ubiquitin ligases (CRLs) comprise the largest known category of ubiquitin ligases. CRLs regulate an extensive number of dynamic cellular processes, including multiple aspects of the cell cycle, transcription, signal transduction, and development. CRLs are multisubunit complexes composed of a cullin, RING H2 finger protein, a variable substrate-recognition subunit (SRS), and for most CRLs, an adaptor that links the SRS to the complex. Eukaryotic species contain multiple cullins, with five major types in metazoa. Each cullin forms a distinct class of CRL complex, with distinct adaptors and/or substrate-recognition subunits. Despite this diversity, each of the classes of CRL complexes is subject to similar regulatory mechanisms. This review focuses on the global regulation of CRL complexes, encompassing: neddylation, deneddylation by the COP9 Signalosome (CSN), inhibitory binding by CAND1, and the dimerization of CRL complexes. We also address the role of cycles of activation and inactivation in regulating CRL activity and switching between substrate-recognition subunits.
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影响因子：
--
作者：
Cope GA;Deshaies RJ
通讯作者：
Deshaies RJ
影响因子：
8
作者：
Chung, J.;Roberts, A. M.;Ohh, M.
通讯作者：
Ohh, M.
影响因子：
11.4
作者：
Brand, M;Moggs, JG;Tora, L
通讯作者：
Tora, L
影响因子：
64.8
作者：
Bashir, T;Dorrello, NV;Pagano, M
通讯作者：
Pagano, M
DOI：
10.1073/pnas.96.16.9124
发表时间：
1999-08-03
影响因子：
11.1
作者：
Galan, JM;Peter, M
通讯作者：
Peter, M