Diversity and specificity in the interaction between Caenorhabditis elegans and the pathogen Serratia marcescens -: art. no. 49
Diversity and specificity in the interaction between Caenorhabditis elegans and the pathogen Serratia marcescens -: art. no. 49
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DOI：
10.1186/1471-2148-4-49
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发表时间：
2004-11-22
影响因子：
3.4
通讯作者：
Ewbank, JJ
中科院分区：
文献类型：
--
作者：
Schulenburg, H;Ewbank, JJ
背景：寄生虫和宿主之间的共同进化军备竞赛被认为在生物体的进化中具有巨大的重要性，可能导致高度动态的生活史变化。在许多情况下，这种军备竞赛的结果被认为是由频率依赖的选择决定的，这取决于宿主易感性和寄生虫毒力的遗传变异，以及宿主和寄生虫之间基因型特异性的相互作用。然而，这两个先决条件的经验证据很少，特别是对于无脊椎动物宿主。我们通过分析自然分离的土壤线虫秀丽隐杆线虫和致病土壤细菌粘质沙雷氏菌之间的相互作用来解决这个问题。结果：我们的分析揭示了i)宿主易感性的显著差异，ii)病原体毒力的显著差异，以及iii)两个物种之间显著的菌株和基因型特异性相互作用。结论：获得的结果支持了先前寄生虫与动物宿主之间高度特异性相互作用普遍存在的观点。至少对于秀丽隐杆线虫，在同一种群的分离株中观察到高特异性，因此它可以为自然条件下的共同进化适应提供基础和/或代表结果。由于秀丽隐杆线虫和粘质线虫都可以进行全面的分子分析，这两个物种为推断这种高度特异性相互作用的分子基础提供了一个有希望的模型系统，这种相互作用尚未在无脊椎动物宿主中探索过。
Background: Co-evolutionary arms races between parasites and hosts are considered to be of immense importance in the evolution of living organisms, potentially leading to highly dynamic life-history changes. The outcome of such arms races is in many cases thought to be determined by frequency dependent selection, which relies on genetic variation in host susceptibility and parasite virulence, and also genotype-specific interactions between host and parasite. Empirical evidence for these two prerequisites is scarce, however, especially for invertebrate hosts. We addressed this topic by analysing the interaction between natural isolates of the soil nematode Caenorhabditis elegans and the pathogenic soil bacterium Serratia marcescens.Results: Our analysis reveals the presence of i) significant variation in host susceptibility, ii) significant variation in pathogen virulence, and iii) significant strain- and genotype-specific interactions between the two species.Conclusions: The results obtained support the previous notion that highly specific interactions between parasites and animal hosts are generally widespread. At least for C. elegans, the high specificity is observed among isolates from the same population, such that it may provide a basis for and/or represent the outcome of co-evolutionary adaptations under natural conditions. Since both C. elegans and S. marcescens permit comprehensive molecular analyses, these two species provide a promising model system for inference of the molecular basis of such highly specific interactions, which are as yet unexplored in invertebrate hosts.