Development of Overgeneral Autobiographical Memory in Offspring of Depressed Mothers.
Development of Overgeneral Autobiographical Memory in Offspring of Depressed Mothers.
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抑郁母亲的后代过度笼统的自传体记忆的发展。
DOI：
10.1080/15374416.2019.1650367
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Gibb,BrandonE
中科院分区：
文献类型：
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作者：
Woody,MaryL;Tsypes,Aliona;Burkhouse,KatieL;Feurer,Cope;Champagne,Katelynn;Gibb,BrandonE
母亲抑郁症增加了后代认知脆弱性的风险，这可能是抑郁症代际传递的潜在机制。人们对抑郁母亲的后代如何发展认知脆弱性，特别是记忆偏见知之甚少。了解记忆偏差的病因可能会导致新的干预目标。因此，目前的研究检查了母亲抑郁症对后代过度自传体记忆（OGM;即，倾向于回忆起不太具体的记忆），这是一种与抑郁症代际传递有关的认知脆弱性。参与者是在后代的生活中有（n= 129）或没有（n = 122）重度抑郁症（MDD）病史的母亲的后代（年龄8-14岁; 51%的女儿，81%的白人）。母亲和后代每6个月完成一次评估，持续2年。与从未患抑郁症的母亲的后代相比，有抑郁症病史的母亲的后代在初始评估时对消极而非积极的提示词回忆起较少的具体记忆，并且这种偏倚在2年的随访中一直保持。对于抑郁症的后代，但不是从来没有抑郁症的母亲，在给定的评估母亲抑郁症状的水平较高，预测在儿童的自传体记忆特异性的前瞻性下降。同样，这一发现是针对消极的，而不是积极的，线索词。这些结果表明，母亲抑郁症对后代OGM的发展有短期和长期的影响，负面的线索，这可能代表了一个可塑性的认知脆弱性MDD的代际传递，可以有针对性的干预。
Maternal depression increases the risk for offspring cognitive vulnerabilities, which may be a mechanism underlying the intergenerational transmission of depression. Little is known about how cognitive vulnerabilities, particularly memory biases, develop in the offspring of depressed mothers. Understanding the etiology of memory biases may lead to novel intervention targets. Therefore, the current study examined the prospective impact of maternal depression on the development of offspring overgeneral autobiographical memory (OGM; i.e., the tendency to recall less specific memories), a cognitive vulnerability implicated in the intergenerational transmission of depression. Participants were offspring (ages 8–14; 51% daughters, 81% Caucasian) of mothers with (n= 129) or without (n= 122) a history of major depressive disorder (MDD) during the offspring’s life. Mothers and offspring completed assessments every 6 months for 2 years. Compared to offspring of never-depressed mothers, offspring of mothers with a history of MDD recalled less specific memories in response to negative, but not positive, cue words at the initial assessment, and this bias was maintained across the 2-year follow-up. For offspring of depressed, but not never-depressed, mothers, higher levels of maternal depressive symptoms at a given assessment predicted prospective decreases in the children’s autobiographical memory specificity. Again, this finding was specific to negative, but not positive, cue words. These results suggest that maternal depression has both short- and long-term effects on the development of offspring OGM to negative cues, which may represent a malleable cognitive vulnerability for the intergenerational transmission of MDD that could be targeted for intervention.