Multifunctional Fe3O4/TaOx Core/Shell Nanoparticles for Simultaneous Magnetic Resonance Imaging and X-ray Computed Tomography
Multifunctional Fe3O4/TaOx Core/Shell Nanoparticles for Simultaneous Magnetic Resonance Imaging and X-ray Computed Tomography
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DOI：
10.1021/ja3016582
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发表时间：
2012-06-27
影响因子：
15
通讯作者：
Hyeon, Taeghwan
中科院分区：
文献类型：
--
作者：
Lee, Nohyun;Cho, Hye Rim;Hyeon, Taeghwan
多模态成像对于准确诊断是高度期望的，因为它可以提供来自每个成像模态的互补信息。在这项研究中，溶胶-凝胶反应的乙醇钽（V）在微乳液中含有Fe 3 O 4纳米粒子（NPs）的合成多功能Fe 3 O 4/TaOx核/壳NPs，这是生物相容性和表现出延长的循环时间。当静脉注射NP时，使用计算机断层扫描（CT）观察肿瘤相关血管，并且磁共振成像（MRI）显示肿瘤的高和低血管区域。
Multimodal imaging is highly desirable for accurate diagnosis because it can provide complementary information from each imaging modality. In this study, a sol-gel reaction of tantalum(V) ethoxide in a microemulsion containing Fe3O4 nanoparticles (NPs) was used to synthesize multifunctional Fe3O4/TaOx core/shell NPs, which were biocompatible and exhibited a prolonged circulation time. When the NPs were intravenously injected, the tumor-associated vessel was observed using computed tomography (CT), and magnetic resonance imaging (MRI) revealed the high and low vascular regions of the tumor.