Transfer Function Analysis of Dynamic Blood Flow Control in the Rat Kidney.
Transfer Function Analysis of Dynamic Blood Flow Control in the Rat Kidney.
复制标题
大鼠肾脏动态血流控制的传递函数分析。
DOI：
10.1007/s11538-016-0168-y
复制
发表时间：
2016
影响因子：
3.5
通讯作者：
Layton,AnitaT
中科院分区：
文献类型：
--
作者：
Sgouralis,Ioannis;Maroulas,Vasileios;Layton,AnitaT
肾血流受生肌反应（MR）和肾小球反馈（TGF）调节。这两种机制不仅可以缓冲稳定的压力扰动，还可以缓冲瞬态的压力扰动。在这项研究中，我们开发了两种肾脏自动调节模型——综合模型和简化模型——并用它们来分析 MR 和 TGF 在缓冲瞬时压力扰动中的各自贡献。两种模型都代表大鼠肾脏的单个肾单位以及相关的脉管系统。综合模型包括血管特性和细胞过程的详细表示。相比之下，简化模型代表了一组最小的关键流程。为了评估不同频率下肾灌注压波动的衰减程度，我们为每个模型推导了传递函数。两种模型的传递函数都预测 45 和 180 mHz 处的共振，分别与 TGF 和 MR、100 mHz 以下的有效自动调节以及 200 mHz 以上的压力扰动放大相关。这些预测与实验结果非常吻合。
Renal blood flow is regulated by the myogenic response (MR) and tubuloglomerular feedback (TGF). Both mechanisms function to buffer not only steady pressure perturbations but also transient ones. In this study, we develop two models of renal autoregulation—a comprehensive model and a simplified model—and use them to analyze the individual contributions of MR and TGF in buffering transient pressure perturbations. Both models represent a single nephron of a rat kidney together with the associated vasculature. The comprehensive model includes detailed representation of the vascular properties and cellular processes. In contrast, the simplified model represents a minimal set of key processes. To assess the degree to which fluctuations in renal perfusion pressure at different frequencies are attenuated, we derive a transfer function for each model. The transfer functions of both models predict resonance at 45 and 180 mHz, which are associated with TGF and MR, respectively, effective autoregulation below100 mHz, and amplification of pressure perturbations above200 mHz. The predictions are in good agreement with experimental findings.