Association of 24-hour cortisol production rates, cortisol-binding globulin, and plasma-free cortisol levels with body composition, leptin levels, and aging in adult men and women
Association of 24-hour cortisol production rates, cortisol-binding globulin, and plasma-free cortisol levels with body composition, leptin levels, and aging in adult men and women
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DOI：
10.1210/jc.2003-030440
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发表时间：
2004-01-01
影响因子：
5.8
通讯作者：
Samuels, MH
中科院分区：
文献类型：
--
作者：
Purnell, JQ;Brandon, DD;Samuels, MH
本研究旨在检验以下假设：通过 24 小时皮质醇生成率 (CPR) 和血浆游离皮质醇水平测量的下丘脑-垂体-肾上腺轴活动与成人体内脂肪增加有关，并且随着年龄的增长，皮质醇水平增加是由于 CPR 增加所致。 54 名体重指数和年龄各异的健康男性和女性志愿者通过气相色谱-质谱法、皮质醇结合球蛋白和 24 小时合并血浆中的游离皮质醇、身体成分和瘦素测量同位素稀释来进行心肺复苏 (CPR) 测量。皮质醇清除率是根据在另一组患有肾上腺功能不全的瘦和肥胖受试者中稳态输注后氢化可的松的 10 小时消失曲线来确定的。尽管心肺复苏随着体重指数和体脂百分比的增加而显着增加，但由于皮质醇清除率增加，游离皮质醇水平仍然独立于身体成分和瘦素水平。然而，男性的心肺复苏和游离皮质醇水平明显高于女性。此外，24小时血浆游离皮质醇水平随着年龄的增长而增加，与心肺复苏的增加相关，与体型无关。下丘脑-垂体-肾上腺轴活动的增加可能在男性与女性以及衰老过程中身体成分和中央脂肪分布的变化中发挥作用。
The present study was designed to examine the hypothesis that hypothalamic-pituitary-adrenal axis activity as measured by 24-h cortisol production rate (CPR) and plasma levels of free cortisol is linked to increased body fat in adults, and that increased cortisol levels with aging results from increased CPR. Fifty-four healthy men and women volunteers with a wide range of body mass indexes and ages underwent measurement of CPR by isotope dilution measured by gas chromatography-mass spectroscopy, cortisol-binding globulin, and free cortisol in pooled 24-h plasma, body composition, and leptin. Cortisol clearance rates were determined from the 10-h disappearance curves of hydrocortisone after steady-state infusion in a separate group of lean and obese subjects with adrenal insufficiency. Although CPR significantly increased with increasing body mass index and percentage body fat, free cortisol levels remained independent of body composition and leptin levels due to increased cortisol clearance rates. CPR and free cortisol levels were, however, significantly higher in men than women. In addition, 24-h plasma free cortisol levels were increased with age in association with increased CPR, independent of body size. This increase in hypothalamic-pituitary-adrenal axis activity may play a role in the alterations in body composition and central fat distribution in men vs. women and with aging.