Potential therapeutic implications of cancer stem cells in glioblastoma.
Potential therapeutic implications of cancer stem cells in glioblastoma.
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DOI：
10.1016/j.bcp.2010.04.035
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发表时间：
2010-09-01
影响因子：
5.8
通讯作者：
Rich, Jeremy N.
中科院分区：
文献类型：
--
作者：
Cheng, Lin;Bao, Shideng;Rich, Jeremy N.
关键词：
胶质母细胞瘤是最常见和致命的原发性脑肿瘤。尽管最近在其他癌症的治疗进展，胶质母细胞瘤的治疗仍然无效，基本上是姑息性的。治疗失败是多种原因的结果，但我们和其他人已经证明，一种称为胶质母细胞瘤干细胞（GSC）的高度致瘤性癌细胞亚群对放疗和化疗表现出相对抵抗力。GSC还通过刺激血管生成促进肿瘤生长，这已被证明是治疗复发性或进行性恶性胶质瘤的有用治疗靶点。癌症干细胞也被假设为全身转移的贡献者。虽然胶质母细胞瘤很少转移到中枢神经系统以外，但胶质母细胞瘤侵入脑结构以防止手术治愈，并且GSC具有极高的侵袭性表型。总的来说，这些研究和其他研究表明，GSC可能是重要的治疗靶点，不仅可以实现治愈，甚至可以减少肿瘤复发并提高总生存率。最近的许多研究表明，GSC与正常的胚胎干细胞和体干细胞共享核心调控途径，但显示出重要的区别，为有用的治疗靶点提供了线索。癌症干细胞假说也可能改变我们在肿瘤成像和生物标志物开发方面的方法，但临床验证仍在等待。在这篇综述中，我们总结了目前对GSC生物学的理解，重点是潜在的抗GSC治疗。
Glioblastoma is the most common and lethal type of primary brain tumor. Despite recent therapeutic advances in other cancers, the treatment of glioblastomas remains ineffective and essentially palliative. The treatment failure is a result of a number of causes, but we and others have demonstrated that a highly tumorigenic subpopulation of cancer cells called glioblastoma stem cells (GSCs) display relative resistance to radiation and chemotherapy. GSCs also contribute to tumor growth through the stimulation of angiogenesis, which has been shown to be a useful therapeutic target in the treatment of recurrent or progressive malignant gliomas. Cancer stem cells also have been hypothesized as a contributor to systemic metastases. While glioblastomas rarely metastasize beyond the central nervous system, glioblastomas invade into brain structures to prevent surgical cure and GSCs have an extremely invasive phenotype. Collectively, these studies and others suggest that GSCs may be important therapeutic targets not only to achieve cure but even reduce tumor relapse and improve overall survival. Many recent studies suggest that GSCs share core regulatory pathways with normal embryonic and somatic stem cells, but display important distinctions that provide clues into useful treatment targets. The cancer stem cell hypothesis may also modify our approaches in tumor imaging and biomarker development, but clinical validation waits. In this review, we summarize the current understanding of GSC biology with a focus on potential anti-GSC therapies.
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影响因子：
5.2
作者：
Bar, Eli E.;Chaudhry, Aneeka;Eberharta, Charles G.
通讯作者：
Eberharta, Charles G.
影响因子：
5.3
作者：
Abdouh, Mohamed;Facchino, Sabrina;Bernier, Gilbert
通讯作者：
Bernier, Gilbert
影响因子：
64.5
作者：
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通讯作者：
Mandel, G
DOI：
10.1073/pnas.0703478104
发表时间：
2007-06-12
影响因子：
11.1
作者：
Dalerba, Piero;Dylla, Scott J.;Clarke, Michael F.
通讯作者：
Clarke, Michael F.
影响因子：
64.8
作者：
通讯作者：
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