Effects of dietary composition on postprandial endothelial function and adiponectin concentrations in healthy humans: a crossover controlled study
Effects of dietary composition on postprandial endothelial function and adiponectin concentrations in healthy humans: a crossover controlled study
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DOI：
10.1093/ajcn/86.4.923
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发表时间：
2007-10-01
影响因子：
7.1
通讯作者：
Ueda, Shinichiro
中科院分区：
文献类型：
--
作者：
Shimabukuro, Michio;Chinen, Ichiro;Ueda, Shinichiro
背景：餐后状态的异常会导致动脉粥样硬化的发生。据报道，餐后高血糖、高甘油三酯血症和高脂血症独立地导致餐后细胞因子激活。然而，尚不清楚哪种膳食成分优先影响健康受试者的餐后内皮功能。目的：我们旨在研究健康受试者的膳食成分与餐后内皮功能的关联。设计：单次摄入高碳水化合物膳食（300 kcal，100%碳水化合物）、高脂肪膳食（30 g 脂肪/m(2)，35%）的影响 在健康受试者中研究了餐后血浆脂联素浓度和反应性充血期间前臂血流量（FBF）的情况。结果：峰值FBF反应和总反应性充血流量（流量债务偿还；FDR）、阻力动脉指数 摄入高碳水化合物和标准测试餐后，内皮功能没有变化，但在摄入高脂肪餐后 120 和 240 分钟有所下降。高脂餐后，峰值 FBF 和 FDR 的降低与血浆游离脂肪酸 (FFA) 浓度的升高密切相关，但与其他生化变量（包括三酰甘油、胰岛素、葡萄糖、总胆固醇、HDL 胆固醇和脂联素）无关。 结论：仅在高脂饮食后，餐后内皮功能才会受损 健康受试者在食用高碳水化合物或标准测试餐后则不会。由于高脂肪餐后的这种内皮功能障碍与 FFA 浓度密切相关，因此餐后状态可能是危险的，主要是通过健康受试者的急性高脂血症来实现。
Background: Abnormalities during the postprandial state contribute to the development of atherosclerosis. Reportedly, postprandial hyperglycemia, hypertriglyceridemia, and hyperlipacidemia independently cause postprandial cytokine activation. However, it is not clear which dietary composition preferentially affects postprandial endothelial function in healthy subjects.Objective: We aimed to examine the associations of dietary composition and postprandial endothelial function in healthy subjects.Design: The effects of a single ingestion of a high-carbohydrate meal (300 kcal, 100% carbohydrate), a high-fat meal (30 g fat/m(2), 35% fat), or a standard test meal (478 kcal; 16.4% protein, 32.7% fat, 50.4% carbohydrate) on postprandial plasma concentrations of adiponectin and forearm blood flow (FBF) during reactive hyperemia were studied in healthy subjects.Results: The peak FBF response and the total reactive hyperemic flow (flow debt repayment; FDR), indexes of resistance artery endothelial function, were unchanged after ingestion of a high-carbohydrate and standard test meal but decreased 120 and 240 min after a high-fat meal. After a high-fat meal, decreases in peak FBF and FDR were well correlated with an increase in plasma free fatty acid (FFA) concentrations but not with the other biochemical variables, including triacylglycerol, insulin, glucose, total cholesterol, HDL cholesterol, and adiponectin.Conclusions: Postprandial endothelial function was impaired only after the high-fat diet and not after the high-carbohydrate or standard test meal in healthy subjects. Because such endothelial dysfunction after a high-fat meal was closely correlated with FFA concentrations, postprandial state could be hazardous, mostly through acute hyperlipacidemia in healthy subjects.