Computational modeling of adhesive contact between a virus and a cell during receptor driven endocytosis
Computational modeling of adhesive contact between a virus and a cell during receptor driven endocytosis
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DOI：
10.1002/pamm.201900161
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发表时间：
2019-11
期刊：
影响因子：
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通讯作者：
T. Wiegold;S. Klinge;R. Gilbert;G. Holzapfel
中科院分区：
文献类型：
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作者：
T. Wiegold;S. Klinge;R. Gilbert;G. Holzapfel
目前的贡献涉及病毒进入细胞的受体密度的变化所决定的。虽然病毒的受体被认为是固定在其表面上，但细胞的受体在其膜内是移动的。接触后，需要局部增加细胞的受体密度，这导致其向病毒扩散。膜在接触区形成包围病毒的包膜。所描述的问题是模拟的基础上的假设，即微分方程的典型的热传输是适合于描述受体的扩散。此外，提出了两个边界条件。第一个条件涉及粘附区前部的通量平衡，其中速度假定与化学势的梯度成比例。第二个条件表示能量平衡方程，其贡献归因于受体的结合、膜的自由能、其曲率和归因于前运动的动能。选定的数值例子显示了受体密度的变化，以及在膜的粘附区的前面的运动。特别注意受体的流动性。
The present contribution deals with the viral entry into a cell dictated by the change of the receptor density. While the receptors of the virus are considered to be fixed on its surface, the ones of the cell are mobile within its membrane. Upon contact, a locally increased receptor density of the cell is required, which causes it to diffuse towards the virus. The membrane inflicts and forms an envelope around the virus in the contact zone. The described problem is simulated on the basis of the assumption that the differential equation typical of the heat transport is suitable to describe the diffusion of receptors. Furthermore, two boundary conditions are proposed. The first condition deals with the balance of fluxes on the front of the adhesion zone, where the velocity is supposed to be proportional to the gradient of the chemical potential. The second condition represents the energy balance equation with contributions due to the binding of receptors, the free energy of the membrane, its curvature and the kinetic energy due to the motion of the front. The selected numerical example shows the change of the receptor density over the membrane as well as the motion of the front of the adhesion zone. Special attention is paid to the mobility of the receptors.