Influenza vaccination in the COVID-19 era
Influenza vaccination in the COVID-19 era
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DOI：
10.1016/j.earlhumdev.2020.105116
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发表时间：
2020-09-01
影响因子：
2.5
通讯作者：
Borg, Michael
中科院分区：
文献类型：
--
作者：
Grech, Victor;Borg, Michael
流感每年在全球传播，儿童和成人发病率高，发病率、死亡率高，现有慢性病恶化。在北半球和南半球，疫情主要发生在各自的冬季。可接种流感疫苗，但仅部分有效。在没有疫苗的情况下，在冬季，新型冠状病毒COVID-19也将与季节性流感同时传播。到目前为止，这两种病毒目前的毒株，合并感染的临床结果似乎并不比单独感染COVID-19明显差。然而，有几种流感病毒在传播，包括即将到来的病毒。同样，COVID-19也有几种菌株，可能还会有更多。本文对这些问题进行了讨论，并在流感基本繁殖数（RO）估计为0.9-2.1的基础上估计了理想的最小流感疫苗接种覆盖率，从而获得或接近群体免疫。有一个强有力的论据表明，在明年冬天之前，每年都要接种流感疫苗，以接近全民覆盖。
Influenza spreads globally annually with significant paediatric and adult attack rates and considerable morbidity, mortality and the exacerbation of extant chronic disease. In the northern and southern hemispheres, outbreaks occur mainly in the respective winter seasons. Influenza vaccination is available but only partially effective. In the absence of a vaccine, in winter, novel coronavirus COVID-19 will also circulate in parallel with seasonal influenza. Thus far it appears that with the current strains of these two viruses, the clinical outcome of co-infection is not significantly worse than infection with COVID-19 alone. However, several strains of influenza circulate, including strains still to come. Similarly, COVID-19 has several strains, with probably more to come. This paper discusses these issues and estimates ideal minimum influenza vaccination coverage based on an estimated influenza Basic Reproduction Number (RO) of 0.9-2.1 so as to obtain herd immunity or approach it. There is a strong argument for attempting near universal population coverage with the annual influenza vaccine leading up to next winter.