THYROTROPHIN RELEASING HORMONE STIMULATES RELEASE OF [3H]‐DOPAMINE FROM SLICES OF RAT NUCLEUS ACCUMBENS in vitro
THYROTROPHIN RELEASING HORMONE STIMULATES RELEASE OF [3H]‐DOPAMINE FROM SLICES OF RAT NUCLEUS ACCUMBENS in vitro
复制标题
促甲状腺激素释放激素体外刺激大鼠伏核切片释放[3H]-多巴胺
DOI：
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发表时间：
1979
影响因子：
7.3
通讯作者：
C. Pycock
中科院分区：
文献类型：
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作者：
R. Kerwin;C. Pycock
促甲状腺激素释放激素（TRH）（25至100 μm）被发现刺激[3 H]-多巴胺从大鼠延髓核的小切片流出，但不刺激大鼠尾状核的类似切片。摄取抑制不是这种作用的原因，因为在10和50 μm浓度下，TRH与10−7 m [3 H]-多巴胺一起孵育时，对小薄片丘脑核积聚放射性的能力没有影响。此外，激素对基础或多巴胺刺激的腺苷酸环化酶没有影响，也没有取代[3 H]-螺哌隆结合，在细胞核的膜制备物中。
Thyrotrophin releasing hormone (TRH) (25 to 100 μm) was found to stimulate the efflux of [3H]‐dopamine from small slices of rat nucleus accumbens, but not from similar slices of rat caudate nucleus. Uptake inhibition was not responsible for this action, since at 10 and 50 μm TRH had no effect on the ability of small slices of nucleus accumbens to accumulate radioactivity when incubated with 10−7 m [3H]‐dopamine. In addition the hormone had no effect on basal or dopamine‐stimulated adenylate cyclase, nor did it displace [3H]‐spiperone binding, in membrane preparations from nucleus accumbens.