Regional differences in semen quality in Europe
Regional differences in semen quality in Europe
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DOI：
10.1093/humrep/16.5.1012
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发表时间：
2001-05-01
影响因子：
6.1
通讯作者：
Skakkebæk, NE
中科院分区：
文献类型：
--
作者：
Jorgensen, N;Andersen, AG;Skakkebæk, NE
最近的报告表明，一些国家的男性精液质量下降，并表明存在地区差异。对来自四个欧洲城市（丹麦哥本哈根、法国巴黎、苏格兰爱丁堡和芬兰图尔库）的 1082 名生育男性的精液样本进行了研究。精液分析标准化，精子浓度评估的实验室间差异得到评估，形态评估集中化。丹麦男性的精子浓度和总数最低，其次是法国和苏格兰男性，芬兰男性的精子数量最高。来自爱丁堡的男性活动精子比例最高，其次是来自图尔库、哥本哈根和巴黎的男性。只有巴黎/爱丁堡和巴黎的区别！ Turku 具有统计学显着性（分别为 P < 0.003 和 P < 0.002）。没有检测到形态学上的显着差异。检测到精子浓度（夏季为冬季的 70%）和精子总数（夏季为冬季的 72%）的一般季节性变化。对“标准化”男性（30 岁、有生育能力、禁射 96 小时）的精液质量进行了评估。通常，冬季/夏季的精子浓度 (x10(6)/ml) 为： Turku 132/93；爱丁堡119/84；巴黎 1.03/73；和哥本哈根98/69，精液质量的这些差异可能表明四个人群的不同环境暴露或生活方式的变化，但是，这种变化是否可以解释这些差异还有待观察。这些数据也可以作为未来欧洲精液质量时间趋势研究的参考点。
Recent reports have indicated a decrease in semen quality of men in some countries, and suggested regional differences. A study was undertaken of semen samples from 1082 fertile men from four European cities (Copenhagen, Denmark; Paris, France; Edinburgh, Scotland; and Turku, Finland). Semen analysis was standardized, inter-laboratory differences in assessment of sperm concentration were evaluated, and morphology assessment centralized. Lowest sperm concentrations and total counts were detected for Danish men, followed by French and Scottish men, Finnish men had the highest sperm counts. Men from Edinburgh had the highest proportion of motile spermatozoa, followed by men from Turku, Copenhagen and Paris. Only the differences between Paris/Edinburgh and Paris! Turku were statistically significant (P < 0.003 and P < 0.002 respectively). No significant differences in morphology were detected. A general seasonal variation in sperm concentration (summer 70% of winter) and total sperm count (summer 72% of winter) was detected. Semen quality of a 'standardized' man (30 years old, fertile, ejaculation abstinence of 96 h) were estimated. Typically, sperm concentrations (x10(6)/ml) for winter/summer were: Turku 132/93; Edinburgh 119/84; Paris 1.03/73; and Copenhagen 98/69, These differences in semen quality may indicate different environmental exposures or lifestyle changes in the four populations, However, it remains to be seen whether such changes can account for these differences. These data may also serve as a reference point for future studies on time trends in semen quality in Europe.