Association between pachychoroid and long-term treatment outcomes of photodynamic therapy with intravitreal ranibizumab for polypoidal choroidal vasculopathy
Association between pachychoroid and long-term treatment outcomes of photodynamic therapy with intravitreal ranibizumab for polypoidal choroidal vasculopathy
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DOI：
10.1038/s41598-020-65346-w
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发表时间：
2020-05-20
影响因子：
4.6
通讯作者：
Obata, Ryo
中科院分区：
文献类型：
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作者：
Azuma, Keiko;Okubo, Atsushi;Obata, Ryo
我们调查了初治息肉状脉络膜血管病变 (PCV) 患者接受玻璃体内雷珠单抗 (IVR) 光动力治疗 (PDT) 的长期治疗反应。回顾性审查了 14 例未经治疗的 PCV 患者接受 IVR PDT 的医疗记录。对患者进行随访并接受额外 IVR 治疗 >= 3 年。评估最佳矫正视力（BCVA）、中央凹厚度（CFT）、血管造影最大线性尺寸（GLD）、息肉消退和中央脉络膜厚度（CCT）。使用单变量和多变量分析研究了这些功能或解剖结果与年龄、基线 CCT、基线 GLD 或脉络膜血管通透性过高 (CVH) 之间的关联。平均 logMAR BCVA 在 3 年时显着改善（0.34 +/- 0.24 至 0.12 +/- 0.29，p=0.003）。 BCVA 的更大改善和首次复发时间的延长与 CVH 显着相关。 3 年内 IVR 复治次数较少与基线 CCT 较厚相关。平均 CCT 在 3 年时显着下降（217 +/- 33 μm 至 197 +/- 48 μm，p=0.003）。 CCT 的较大下降与 3 年内 IVR 复治次数增多以及 CVH 的缺失显着相关。这些结果表明，对于接受 PDT 和 IVR 联合治疗的初治 PCV 患者，基线时的脉络膜肥厚特征与长期功能和解剖结果相关。
We investigated long-term treatment responses in patients with treatment-naive polypoidal choroidal vasculopathy (PCV) undergoing photodynamic therapy (PDT) with intravitreal ranibizumab (IVR). The medical charts of 14 patients with treatment-naive PCV who underwent PDT with IVR were retrospectively reviewed. Patients were followed up and treated with additional IVR for >= 3 years. Best-corrected visual acuity (BCVA), central foveal thickness (CFT), greatest linear dimension (GLD) on angiography, polyp regression and central choroidal thickness (CCT) were assessed. Associations between these functional or anatomic outcomes with age, baseline CCT, baseline GLD or choroidal vascular hyperpermeability (CVH) were investigated using univariate and multivariate analysis. Mean logMAR BCVA improved significantly at 3 years (0.34 +/- 0.24 to 0.12 +/- 0.29, p=0.003). Greater BCVA improvement and longer time to first recurrence was significantly associated with CVH. Fewer number of IVR retreatment within 3 years was associated with thicker baseline CCT. Mean CCT significantly decreased at 3 years (217 +/- 33 mu m to 197 +/- 48 mu m, p=0.003). Greater decrease of CCT was significantly associated both with greater number of IVR retreatment within 3 years and absence of CVH. These results showed that pachychoroid characteristics at baseline was associated long-term functional and anatomic outcomes in patients with treatment-naive PCV who had undergone combination PDT and IVR.