Relationship between plasma and hepatic cytosolic levels of ornithine decarboxylase (ODC) and thymidine kinase (TK) in 70% hepatectomized rats.
Relationship between plasma and hepatic cytosolic levels of ornithine decarboxylase (ODC) and thymidine kinase (TK) in 70% hepatectomized rats.
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％20血浆％20和％20肝％20细胞质％20水平％20的％20鸟氨酸％20脱羧酶％20（ODC）％20和％20胸苷％20激酶％20（TK）％20在％2070％％20肝切除％20大鼠之间的关系％20。
DOI：
10.1007/bf01318198
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发表时间：
1991
影响因子：
3.1
通讯作者：
Francavilla,A
中科院分区：
文献类型：
--
作者：
Polimeno,L;Azzarone,A;Dell'Aquila,P;Amoruso,C;Barone,M;Angelini,A;VanThiel,DH;Francavilla,A
鸟氨酸脱羧酶（ODC）和胸苷激酶（TK）是DNA合成的重要酶，DNA合成是细胞更新和再生的关键过程。因此，它们已经被用作组织再生的替代标记物。本研究测定了70%肝切除后大鼠血浆和再生肝组织中这两种酶的活性。结果表明，血浆中这些酶活性的变化反映了肝组织中获得的变化。因此，ODC和TK的血液水平可以用作监测肝脏和可能的其他组织的再生反应的侵入性较小且非破坏性的手段。
Ornithine decarboxylase (ODC) and thymidine kinase (TK) are enzymes important for DNA synthesis, a process that is critical for cell renewal and regeneration. As such, they already have been used as surrogate markers of regeneration in tissue. In the present study, the activity of these two enzymes in plasma of rats and regenerating hepatic tissue following a 70% hepatectomy were determined. The results demonstrate that the changes in these enzyme activities in plasma reflect the changes obtained in the liver tissue. Thus, blood levels of ODC and TK can be used as a less invasive and nondestructive means of monitoring the regenerative response of the liver and possibly other tissues.