Association of Brachial-Ankle Pulse Wave Velocity with Asymptomatic Intracranial Arterial Stenosis in Hypertension Patients
Association of Brachial-Ankle Pulse Wave Velocity with Asymptomatic Intracranial Arterial Stenosis in Hypertension Patients
复制标题
高血压患者臂踝脉搏波速度与无症状颅内动脉狭窄的关系
DOI：
10.1016/j.jstrokecerebrovasdis.2016.04.008
复制
发表时间：
2016-08-01
影响因子：
2.5
通讯作者：
Zhu, Dingliang
中科院分区：
文献类型：
--
作者：
Wang, Yan;Zhang, Jin;Zhu, Dingliang
背景：颅内动脉狭窄是亚洲人缺血性中风的常见原因。因此，我们试图在 834 名无卒中高血压患者中探讨臂踝脉搏波速度与颅内动脉狭窄的关系。方法：通过计算机断层血管造影评估颅内动脉狭窄。通过自动袖带装置测量臂踝脉搏波速度。结果：臂踝脉搏波速度的最高十分之一与颅内动脉狭窄显着相关（P = .027，比值比 = 1.82；95% 置信区间：1.07-3.10）。臂踝脉搏波速度最高十分之一的患者表现出颅内动脉狭窄的风险比整个人群高出 56%，这在 65 岁以下的患者中更为显着。我们还发现臂踝脉搏波速度与颅内动脉狭窄和同型半胱氨酸有关。结论：我们的研究表明，高血压患者，尤其是相对年轻的受试者，臂踝脉搏波速度与无症状颅内动脉狭窄之间存在关联。臂踝脉搏波速度可能是一种相对简单且可重复的测量方法，可用于检测颅内动脉狭窄高风险的高血压患者。
Background: Intracranial arterial stenosis is a common cause of ischemic stroke in Asians. We therefore sought to explore the relationship of brachial-ankle pulse wave velocity and intracranial arterial stenosis in 834 stroke-free hypertensive patients. Methods: Intracranial arterial stenosis was evaluated through computerized tomographic angiography. Brachial-ankle pulse wave velocity was measured by an automated cuff device. Results: The top decile of brachial-ankle pulse wave velocity was significantly associated with intracranial arterial stenosis (P = .027, odds ratio = 1.82; 95% confidence interval: 1.07-3.10). The patients with the top decile of brachial-ankle pulse wave velocity showed 56% higher risk for the presence of intracranial arterial stenosis to the whole population, which was more significant in patients younger than 65 years old. We also found that brachial-ankle pulse wave velocity related to both intracranial arterial stenosis and homocysteine. Conclusion: Our study showed the association of brachial-ankle pulse wave velocity with asymptomatic intracranial arterial stenosis in hypertension patients, especially in relative younger subjects. Brachial-ankle pulse wave velocity might be a relatively simple and repeatable measurement to detect hypertension patients in high risk of intracranial arterial stenosis.