Indigenous use and bio-efficacy of medicinal plants in the Rasuwa District, Central Nepal
Indigenous use and bio-efficacy of medicinal plants in the Rasuwa District, Central Nepal
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DOI：
10.1186/1746-4269-6-3
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发表时间：
2010-01-26
影响因子：
3.6
通讯作者：
Shrestha, Krishna K.
中科院分区：
文献类型：
--
作者：
Uprety, Yadav;Asselin, Hugo;Shrestha, Krishna K.
背景：通过揭示历史和现在的植物使用，民族植物学有助于药物发现和社会经济发展。尼泊尔是药用植物的天然宝库。虽然在该国进行了几项民族植物学研究，但许多地区仍未探索。此外，很少有研究比较土著植物的使用与报告的phytochemical和pharmacological properties.Methods：民族药理学数据收集在尼泊尔中部的Rasuwa区进行采访和焦点小组讨论与当地人。计算了被调查者一致性因子（F-IC），以估计药用植物的使用变异性。通过比较土著植物的使用与从现有文献的审查中确定的植物化学和药理学特性，评估了生物功效。标准被用来确定高优先级药用植物species.Results：共有60个药用配方从56种植物被记录。药用植物被用来治疗各种疾病和失调，用于肠胃问题的种类最多，其次是发烧和头痛。草药是药用植物的主要来源（占物种的57%），其次是树木（23%）。所有疾病类别的平均F-IC值为0.82，表明与其他地方进行的类似研究相比，知情者的一致性较高。高F-IC值获得眼科问题，牙痛，肾脏问题，月经失调，表明传统上用于治疗这些疾病的物种是值得寻找的生物活性化合物：落新妇rivularis，Berthalomaasiatica，沙棘，Juniperus recurva，和多枝獐牙菜。90%的对应关系，发现当地的植物使用和报告的植物化学成分和药理学特性的30个物种的信息。16种药用植物被列为优先物种，其中13种也被列为优先在全国范围内的政府classification.Conclusions：塔芒人拥有丰富的民族药理学知识。这项研究确定了许多高价值和高优先级的药用植物物种，表明通过可持续收集和贸易实现经济发展的巨大潜力。
Background: By revealing historical and present plant use, ethnobotany contributes to drug discovery and socioeconomic development. Nepal is a natural storehouse of medicinal plants. Although several ethnobotanical studies were conducted in the country, many areas remain unexplored. Furthermore, few studies have compared indigenous plant use with reported phytochemical and pharmacological properties.Methods: Ethnopharmacological data was collected in the Rasuwa district of Central Nepal by conducting interviews and focus group discussions with local people. The informant consensus factor (F-IC) was calculated in order to estimate use variability of medicinal plants. Bio-efficacy was assessed by comparing indigenous plant use with phytochemical and pharmacological properties determined from a review of the available literature. Criteria were used to identify high priority medicinal plant species.Results: A total of 60 medicinal formulations from 56 plant species were documented. Medicinal plants were used to treat various diseases and disorders, with the highest number of species being used for gastro-intestinal problems, followed by fever and headache. Herbs were the primary source of medicinal plants (57% of the species), followed by trees (23%). The average F-IC value for all ailment categories was 0.82, indicating a high level of informant agreement compared to similar studies conducted elsewhere. High F-IC values were obtained for ophthalmological problems, tooth ache, kidney problems, and menstrual disorders, indicating that the species traditionally used to treat these ailments are worth searching for bioactive compounds: Astilbe rivularis, Berberis asiatica, Hippophae salicifolia, Juniperus recurva, and Swertia multicaulis. A 90% correspondence was found between local plant use and reported plant chemical composition and pharmacological properties for the 30 species for which information was available. Sixteen medicinal plants were ranked as priority species, 13 of which having also been prioritized in a country-wide governmental classification.Conclusions: The Tamang people possess rich ethnopharmacological knowledge. This study allowed to identify many high value and high priority medicinal plant species, indicating high potential for economic development through sustainable collection and trade.