Progesterone regulation of synaptic transmission and plasticity in rodent hippocampus
Progesterone regulation of synaptic transmission and plasticity in rodent hippocampus
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DOI：
10.1101/lm.1124708
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发表时间：
2008-11-01
影响因子：
2
通讯作者：
Thompson, Richard F.
中科院分区：
文献类型：
--
作者：
Foy, Michael R.;Akopian, Garnik;Thompson, Richard F.
卵巢激素通过引起神经活动的变化来影响记忆的形成。采用离体海马切片研究了不同浓度孕酮（P4）对与长期增强（LTP）和长期抑郁（LTD）相关的突触传递和可塑性的影响。细胞外研究表明，最高浓度的P4 （10(-6) M）降低了基线突触传递和LTP的大小，但不影响LTD。细胞内研究表明，P4的作用至少部分是由GABA(A)活性介导的。这些结果证实了P4对突触传递的一般影响，突触可塑性的多种形式，以及P4在海马中的可能作用机制。
Ovarian hormones influence memory formation by eliciting changes in neural activity. The effects of various concentrations of progesterone (P4) on synaptic transmission and plasticity associated with long-term potentiation (LTP) and long-term depression (LTD) were studied using in vitro hippocampal slices. Extracellular studies show that the highest concentration of P4 tested (10(-6) M) decreased the baseline synaptic transmission and magnitude of LTP, but did not affect LTD. Intracellular studies suggest the P4 effect to be mediated, at least in part, by GABA(A) activity. These results establish a general effect of P4 on synaptic transmission, multiple forms of synaptic plasticity, and a possible mechanism of P4 action in hippocampus.